CHARLOTTE, NC
Ulcerative Colitis Clinical Trials
6 studies are enrolling for ulcerative colitis near Charlotte NC right now. Notably, two of them have no dummy group anywhere in them. You may be compensated for your time, and no insurance is needed.
6
Open Near Charlotte
2
With No Dummy
+/- $100
Per Visit
New here? Read how this page works
First, two numbers decide which of these will take you, and most people have never been told either. So here is the order to work through.
- Ask for your Mayo score in writing. Because nearly every study here gates on it, and most want a 5 to 9.
- Ask for the camera part of that score separately. Notably, most studies want a 2 or a 3, which means visible damage rather than symptoms alone.
- Ask for a faecal calprotectin. In fact, it measures swelling in the gut specifically, and it is far more useful here than a general blood test.
- Finally, tap the button. Then we check you against all of them at once and tell you when a new one opens.
Of course, checking never signs you up for anything. You are only seeing where you might fit.
The 6 Studies Enrolling Near Charlotte Right Now
Every one of them is open today. So check your eligibility, or read the full record on ClinicalTrials.gov.
The two with no dummy anywhere in them
Everyone in these gets a real drug. So if the dummy question is what is stopping you, start here.
The Only One Here With No Dummy At All
Boehringer Ingelheim / Early study
Everyone in this one gets the real drug. There is no dummy group anywhere in it. First comes a drip every four weeks for 12 weeks. Then responders self inject at home every four weeks for up to two years. Notably, the entry rules here are the widest of any Charlotte study on this page.
Payment is not published.
Check eligibility →More details
Why researchers are excited: most people asking about studies are really asking about the dummy. Meanwhile, this one removes that question completely.
Who this study is looking for
- Age 18 to 80, colitis confirmed at least 3 months ago
- Also, confirmed by both camera and tissue sample
- Besides that, A newer drug did not work, stopped working, or you simply stopped it
- Finally, willing to use reliable contraception
Probably not a fit if: a pouch, an ileostomy or a colostomy rules you out. Also, a known fixed narrowing in the bowel excludes you. Notably, past bowel surgery is sometimes allowed case by case, which is rare here.
- Placebo group: None at all. Everyone gets the real drug and knows it.
- How long: 12 weeks of drips. Then up to two years of self injections if you respond.
- Clinic visits: Every four weeks throughout, which is published clearly.
- Phone calls: Not published on the public record.
- Most invasive part: A camera test of the bowel is required. At least two are needed. Also, the drip part means clinic time every month.
- Setting: Outpatient.
- Where it runs: Atrium Health Gastroenterology and Hepatology, Charlotte NC 28204.
- Drive from Charlotte: All of these sit inside the metro, so no long drive is involved.
- The entry rule is unusually broad. Stopping a newer drug for any reason counts, not only failure. So ask about this one even if you simply came off something.
- Full study record: View on ClinicalTrials.gov →
An Approved Drug, in an Ordinary Clinic
Takeda / Approved drug study
This is not a test of whether the drug works. That is already settled, because it is approved and on the market. Instead it looks at using it in ordinary community clinics. You get drips for six weeks, then a pen you use yourself. So everyone here receives a licensed treatment.
Payment is not published.
Check eligibility →More details
Why researchers are excited: most studies run at big academic centres. However, this one deliberately runs where most people actually get their care.
Who this study is looking for
- Age 18 to 80, with a Mayo score of 6 to 12
- Also, A camera score of 2 or 3
- Besides that, steroids or newer drugs failed, stopped working, or were not tolerated
- Finally, vaccinations up to date for this drug
Probably not a fit if: any past use of this drug family rules you out for good. That means ever, not recently. Also, more than two failed newer drugs excludes you, and so does taking one for a skin condition.
- Placebo group: None. Everyone gets the approved drug.
- How long: About a year of treatment. Then a final check about 18 weeks after the last dose.
- Clinic visits: Several across the year, with set checks at weeks 6, 14, 26 and 52.
- Phone calls: Not published on the public record.
- Most invasive part: A camera test of the bowel is required. Two are needed, at the start and at week 52. Also, stool and blood tests happen through the year.
- Setting: Outpatient.
- Where it runs: Charlotte Gastroenterology and Hepatology, Charlotte NC 28207; Piedmont Healthcare, Statesville NC 28625.
- Drive from Charlotte: All of these sit inside the metro, so no long drive is involved.
- The exclusion here catches people out. Any anti-integrin drug ever taken rules you out. So check your records for vedolizumab or natalizumab before you call.
- Full study record: View on ClinicalTrials.gov →
The four testing something new against a dummy
Each of these tests a drug that is not approved yet. However, one caps your time on a dummy at 12 weeks.
The One Study Running in Both Cities
Sanofi with Teva / Late stage antibody
Duvakitug blocks a signal called TL1A. Researchers think that signal drives both the swelling and the scarring. Notably, no approved drug for this condition targets scarring at all. It is given as an injection or a drip across 12 weeks. This is the only study here with sites in both metros.
Payment is not published.
Check eligibility →More details
Why researchers are excited: TL1A is the most watched target in bowel disease right now. Also, three separate companies are racing on it, which tells you how seriously it is taken.
Who this study is looking for
- Age 18 to 80, with colitis confirmed at least 3 months ago
- Also, moderate to severe disease on the modified Mayo score
- Besides that, usual drugs failed, stopped working, or were not tolerated
- Finally, A steady dose of your current medicine going in
Probably not a fit if: rectum only disease will not get you in. Also, Crohn’s or undecided colitis rules you out. Notably, any earlier anti-TL1A drug excludes you for good, so say if you have had one.
- Placebo group: Yes in the main part, though one sub study is open label with no dummy at all.
- How long: Up to 35 weeks. That covers screening, 12 weeks of treatment, and possibly 12 more.
- Clinic visits: Up to 8 visits, or up to 15 if you go into the extended part.
- Phone calls: Not published on the public record.
- Most invasive part: A camera test of the bowel is required. You would have at least two, at the start and at week 12. Also, small samples are taken during them.
- Setting: Outpatient.
- Where it runs: OnSite Clinical Solutions, Charlotte NC 28211; Monroe Biomedical Research, Monroe NC 28112; Biocentric Health Research Partner, West Columbia SC 29169.
- Drive from Charlotte: All of these sit inside the metro, so no long drive is involved.
- Ask what happens after week 12. The follow on study has no site in either metro.
- Full study record: View on ClinicalTrials.gov →
A Pill Instead of an Injection
Janssen / Late stage tablet
Most modern drugs for this are injections or drips. However, this one is a pill you swallow. It blocks the same IL-23 target that the injected drugs hit. So the real question is whether a tablet can match a needle. It covers both getting you well and keeping you well.
Payment is not published.
Check eligibility →More details
Why researchers are excited: if a pill works as well as an injection here, it changes what treatment looks like day to day. Also, it is the first of its kind to reach late stage testing.
Who this study is looking for
- Colitis confirmed at least 12 weeks ago, by camera and sample
- Also, A modified Mayo score of 5 to 9
- Besides that, A camera score of 2 or 3, so visible damage
- Finally, either usual drugs failed, or newer drugs failed
Probably not a fit if: a stoma bag rules you out. Also, any history of a fistula does too. Notably, bowel surgery in the last 24 weeks excludes you as well.
- Placebo group: Yes for adults. However, the teenage part is open label with no dummy.
- How long: Treatment then maintenance. The main answer comes in January 2028.
- Clinic visits: Not published on the public record.
- Phone calls: Not published on the public record.
- Most invasive part: A camera test of the bowel is required. A camera test at the start is read by a central team. So it must be filmed rather than simply described.
- Setting: Outpatient.
- Where it runs: Atrium Health, Charlotte NC 28204.
- Drive from Charlotte: All of these sit inside the metro, so no long drive is involved.
- The Rock Hill site has closed. The trial still reads as recruiting overall, but that site is finished. Only the Charlotte site is open, so ask for Atrium Health by name.
- Full study record: View on ClinicalTrials.gov →
Twelve Weeks of Dummy, Then Everyone Gets the Drug
Genentech / Mid stage study
The dummy period here is deliberately short. After 12 weeks, everyone moves onto the real drug for 40 more weeks. In fact, that happens whether or not you responded. So the most you would spend on a dummy is about three months. The design exists to limit exactly that.
Payment is not published.
Check eligibility →More details
Why researchers are excited: the fear of losing a year to a dummy keeps people out of studies. Meanwhile, this design caps that risk at 12 weeks and says so up front.
Who this study is looking for
- Colitis diagnosed at least 3 months ago
- Also, moderate to severe disease on the modified Mayo score
- Besides that, usual or newer drugs failed, stopped working, or were not tolerated
- Finally, age 18 or over, with no upper limit given
Probably not a fit if: a large bowel removal rules you out. Also, any earlier anti-TL1A drug does too. Notably, if an IL-12 or IL-23 drug has already failed you, that excludes you here.
- Placebo group: Yes, but only for the first 12 weeks. Then everyone gets the real drug for 40 weeks.
- How long: About 15 months in total, counting screening and the long extension.
- Clinic visits: Not published on the public record.
- Phone calls: Not published on the public record.
- Most invasive part: A camera test of the bowel is required. At least two are needed, at the start and at week 12.
- Setting: Outpatient.
- Where it runs: Monroe Biomedical Research, Monroe NC 28112.
- Drive from Charlotte: Monroe is about 30 minutes south east of the city.
- Ask what the drug actually targets. The public record does not name the target, which is unusual. So ask the site directly before you decide.
- Full study record: View on ClinicalTrials.gov →
Healing Judged Under a Microscope
Roche / Late stage antibody
Afimkibart blocks the same TL1A signal as the study above. However, this one measures success differently. Most studies stop at how the lining looks through a camera. Meanwhile, this checks the tissue under a microscope too. That is a harder bar to clear.
Payment is not published.
Check eligibility →More details
Why researchers are excited: looking normal on camera and being normal under a microscope are not the same thing. Also, the microscope result predicts flares better.
Who this study is looking for
- Confirmed colitis, moderate to severe on the Mayo score
- Also, age 16 to 80, weighing at least 40 kg
- Besides that, at least one usual or newer drug failed or was not tolerated
- Finally, up to date with bowel cancer screening, which is an unusual ask
Probably not a fit if: a stoma bag or a pouch rules you out. Also, liver duct disease called PSC excludes you. Notably, any earlier anti-TL1A drug does too, and cancer within five years.
- Placebo group: Yes. It is a blinded study against a dummy, and the split is not published.
- How long: The main answer comes at week 12. Meanwhile, safety checks run about 30 weeks.
- Clinic visits: Not published on the public record.
- Phone calls: Not published on the public record.
- Most invasive part: A camera test of the bowel is required. At least two are needed. Also, tissue samples are taken and graded.
- Setting: Outpatient.
- Where it runs: Charlotte Gastroenterology and Hepatology, Charlotte NC 28207.
- Drive from Charlotte: All of these sit inside the metro, so no long drive is involved.
- Get your screening done first. This study wants you current on bowel cancer screening. So a lapsed colonoscopy can hold up your entry.
- Full study record: View on ClinicalTrials.gov →
Not sure which one fits you?
First, answer a few quick health questions. Then we check you against all 6 at once. Also, no account and no paperwork.
See if I may fit one of these studies →What Is Actually Changing in Ulcerative Colitis
Three companies are racing on the same new target, and one of them is testing a pill.
Where It Sits, and Why That Matters
This disease only ever affects the large bowel and the rectum. It starts at the rectum and spreads upward in one unbroken stretch. So there are no healthy gaps in between, which is how a doctor tells it apart from Crohn’s. Also, it stays in the lining rather than going through the whole wall.
That Depth Explains the Complications You Do Not Get
Because it stays shallow, it does not cause the tunnels and abscesses that Crohn’s causes. Meanwhile, Crohn’s goes through the full thickness of the bowel wall, which is why it does. So the two diseases need different studies and different drugs. In fact, mixing them up is one of the commonest reasons somebody is screened out.
Two Numbers Decide Whether a Study Will Take You
The first is the modified Mayo score, which runs from 0 to 9. Most studies here want 5 to 9. The second is the camera part of that score, and most want a 2 or a 3. So ask for both numbers in writing after your next camera test. Notably, without them you cannot tell which studies fit.
Ask for Faecal Calprotectin By Name
It is a stool test, and it measures swelling in the gut specifically. That makes it far more useful than a general blood test. Studies often treat a result under 250 as settled down. Also, it is cheap and it avoids a camera test, so it is worth asking about directly.
CRP Can Look Normal While You Are Flaring
CRP is a general blood marker of swelling anywhere in the body. Studies often call under 5 normal. However, plenty of people with active bowel disease have a normal CRP. So a normal result does not mean you are fine, and it should not end the conversation.
Healing Now Means More Than Feeling Better
The old goal was symptom control. Meanwhile, the goal now is that the lining looks normal through a camera. Newer studies go further and check the tissue under a microscope. In fact, one study on this page uses that microscope result as a main measure.
TL1A Is the Target Everyone Is Chasing
Three separate drugs on this page block the same signal, called TL1A. Researchers think it drives both the swelling and the scarring. Notably, no approved drug targets scarring at all today. However, taking any one of these three permanently rules you out of the other two.
Icotrokinra: The Pill in a Field of Injections
Nearly every modern drug for this is an injection or a drip. So a tablet that blocks the same target would be a real change in daily life. That is what one study here is testing. Also, it is the first of its kind to get this far.
Guselkumab: Approved in 2024, and Now the Benchmark
Guselkumab was approved for this disease in September 2024. It blocks IL-23, and it healed the lining in a good share of people. So it changed what a new drug has to beat. Meanwhile, it also gave people who had run out of options something that works.
Ulcerative Colitis Help Near You
Start with a gastroenterologist rather than a general clinic. Ask for your Mayo score, your camera score and a faecal calprotectin in writing. Also, ask whether your last camera test was filmed, because studies often need a central team to read it. Generally, your own doctor can refer you.
Research Sites Near Charlotte
Five research sites across the metro carry these six studies. But sites add new studies all the time, so it is worth knowing what sits near you.
Atrium Health
Multiple Charlotte locations / 161+ active studies
Crohn’s, Heart Failure, COPD, Dementia, Type 2 Diabetes, Hypertension
Charlotte’s biggest health system. It is tied to Wake Forest University School of Medicine. Also, it runs far more trials than anyone else nearby.
Visit Website →
American Health Research Network
Ballantyne, NC 28277 / 25 to 30+ active studies
Asthma, COPD, Chronic Cough, Type 2 Diabetes
Led by Dr. Selwyn Spangenthal. It is the biggest private lung research group in Charlotte. Specifically, it has 4 offices: Charlotte, Rock Hill, Lake Norman, and Charleston.
Visit Website →
Monroe Biomedical Research
Monroe, NC / 17+ active studies
Asthma, COPD, Hypertension, Obesity, Ulcerative Colitis
Notably, one of the 5 busiest research sites in the country. Its 6,300 sq ft space can host overnight stays. It is also an SCRS Global Impact Partner.
Visit Website →
Clinical Research of Gastonia
Gastonia, NC / 11+ active studies
Asthma, COPD, Chronic Cough, Idiopathic Hypersomnia
Led by Dr. Anup Banerjee. Its 3,500 sq ft space sits next to CaroMont Regional Medical Center. Also, it has been running for over 10 years.
Visit Website →
OnSite Clinical Solutions
Ballantyne, NC 28277 / 10+ active studies
Ulcerative Colitis, Crohn’s, COPD, Heart Failure, Atopic Dermatitis
It works with Charlotte doctors in heart, gut, skin, nerve, and joint care. Besides, it runs studies from Phase I through Phase IV.
Visit Website →
Flourish Research
Matthews, NC 28105 / 4+ active studies
Alzheimer’s Disease, Early Alzheimer’s, Alzheimer’s-Related Psychosis
Led by Dr. M. Reza Bolouri. He has 20+ years in Alzheimer’s research. The site is an Alzheimer’s Center of Excellence. In fact, its network has finished 5,500+ trials.
Visit Website →
New Hope Clinical Research
SouthPark, NC 28211 / 4+ active studies
Major Depression, Schizophrenia, Bipolar Disorder
Led by Dr. Kurian Abraham. It runs Phase I through IV studies and has 30 beds for overnight stays. Its last FDA audit came back clean. Also, it has finished 200+ brain studies.
Visit Website →
Queen City Clinical Research
SouthPark, NC 28211 / 2+ active studies
Chronic Pain, Chronic Migraine, Osteoarthritis
Led by Dr. Leonardo Kapural, a former Cleveland Clinic professor. Notably, he has written 200+ journal articles. On top of that, many call this the biggest pain research site in the country.
Visit Website →
Novant Health
Multiple Charlotte locations / Several active studies
Cardiovascular Disease, Obesity, Hypertension
One of the biggest health systems in the Carolinas. Its Heart and Vascular Institute runs heart studies and sees a lot of patients.
Visit Website →
DLVSC
4 Charlotte-area offices / 1+ active studies
Eczema, Psoriasis, Rosacea
Led by Dr. Gilly Munavalli. This award-winning skin practice owns 50+ FDA-approved lasers and devices. Also, it has its own research team.
Visit Website →
DelRicht Research
South Charlotte, NC 28210 / 1+ active studies
Bipolar Disorder, Bipolar Depression
Part of a national network of mental health research sites. Currently, it runs the azetukalner bipolar depression trial in Charlotte. Previously, it ran other mental health studies.
Visit Website →
TMS of the Carolinas
South Charlotte, NC 28210 / 1+ active studies
Major Depression, Treatment-Resistant Depression
A specialty site for brain stimulation care. It runs the fast TMS study that packs 6 weeks into 2.
Visit Website →What to Expect in an Ulcerative Colitis Study
New to studies? Here is how one works, step by step.
01
Prescreening
First comes a short phone call or online form. Also, it takes about 10 to 15 minutes. The staff check whether you might fit. Then they tell you what is open.
02
Screening Visit
Next the clinic runs the tests that decide it, which usually means blood work. Also, they go through the consent form line by line, and you can bring somebody with you.
03
Treatment Period
Then the study begins. So you take the study drug or the placebo on the agreed schedule. Meanwhile, your own doctor keeps managing everything else.
04
Follow-Up
Finally, there is a check in period at the end. Also, your own doctor gets the results, and you can stop at any point without affecting your care.
Ulcerative Colitis Trial FAQs
Real answers about ulcerative colitis studies near Charlotte NC.
Is there a study for this near Charlotte?
Yes, six are open, spread across five clinics in the metro. Two of them have no dummy group at all, and one of those uses a drug that is already approved. Meanwhile, the other four test drugs that are not approved yet, against a dummy. Notably, one of those four caps your dummy time at 12 weeks and then gives everyone the real drug.
Will I get a dummy?
It depends which study, so ask this first rather than last. Some here have no dummy at all, because everyone gets a real drug. Meanwhile, others test a new drug against a dummy and do not publish the split. Also, one caps your time on a dummy at 12 weeks and then moves everyone onto the real drug.
Will I have to stop my current medicine?
Usually you must be on a steady dose rather than off everything, which surprises people. Several studies here need you stable on what you already take. However, the exact wash out period is not published for most of them. So ask the clinic for the number in weeks before you plan anything.
What is a Mayo score?
It is how active your disease is, in one number, and it runs from 0 to 9. It combines stool frequency, bleeding, what the camera sees and a doctor’s rating. Generally, 5 to 9 counts as moderate to severe, and that is the usual entry bar here. So ask for it in writing after your next camera test.
Do I have to have a colonoscopy?
Yes, for the drug studies, and usually more than one. Most need one at the start and another at about 12 weeks. Also, several take small tissue samples during them. However, the device study in Columbia does not list one as a scheduled study procedure.
What is faecal calprotectin?
It is a stool test that measures swelling in the gut specifically. That makes it more useful here than CRP, which is a general blood marker. Notably, CRP can look completely normal while your bowel is inflamed. So ask for the stool test by name rather than settling for a blood result.
What is this TL1A everyone mentions?
It is a signal that researchers think drives both the swelling and the scarring. Three separate drugs on this page block it, which tells you how seriously it is taken. However, taking any one of the three rules you out of the other two permanently. So mention any past study drug by name when you call.
Is it different from Crohn’s disease?
Yes, and studies will not mix them up. This one stays in the large bowel and rectum, in one unbroken stretch, and only in the lining. Meanwhile, Crohn’s can appear anywhere from mouth to bottom, in patches, through the whole wall. So an undecided diagnosis usually rules you out of both.
Does it cost anything to check?
No. There is no cost, and no insurance is needed. Tether is a nonprofit list, so we do not run studies and we are not paid to send you anywhere. Also, checking never enrolls anyone in anything. You would always call the clinic yourself.
Where can I get help near Charlotte NC?
Atrium Health and Novant Health both run bowel services across the metro, and Charlotte Gastroenterology and Hepatology runs several of these studies. Also, ask for a gastroenterologist rather than a general clinic. Generally, your own doctor can refer you. Meanwhile, if nobody has given you a Mayo score, ask for it by name at your next visit.
Ready to Explore a Study?
Check your eligibility, or just reach out to our Charlotte team. No pressure. Also, no sales pitch.
← Back to All Clinical TrialsSources
- SUNSCAPE-1, duvakitug for ulcerative colitis, ClinicalTrials.gov NCT07184996
- Icotrokinra oral tablet for ulcerative colitis, ClinicalTrials.gov NCT07196748
- RO7837195 induction with active extension, ClinicalTrials.gov NCT06979336
- Ametrine-2, afimkibart for ulcerative colitis, ClinicalTrials.gov NCT06588855
- BI 3032950, open label with no placebo, ClinicalTrials.gov NCT06636656
- PANORAMA, vedolizumab in community clinics, ClinicalTrials.gov NCT06581328
- BOOM-IBD2, sacral nerve stimulation device, ClinicalTrials.gov NCT06571669
- Johnson & Johnson: guselkumab approved for ulcerative colitis, 11 September 2024
- University of Chicago: on the therapeutic ceiling in ulcerative colitis
- Yale Medicine: monitoring inflammation and what mucosal healing means
Study details and per-site recruiting status verified against ClinicalTrials.gov on August 16, 2026. Every site row was read individually, because a study can read as recruiting while a particular clinic has closed. One study here lists its Rock Hill site as completed while the study overall still recruits. Study availability and criteria change; the research clinic confirms everything before you enroll.