CHARLOTTE, NC

Blood Clot Clinical Trials

One blood clot study is enrolling inside Charlotte, though its rules are narrow. Also, three more are within a drive, and none of the four uses a dummy procedure. Compensation is provided for eligible participants.

Inside Charlotte

Worth Knowing About

+/- $100

Per Visit

New here? Read how this page works

First, these four cover very different situations, and two of them enroll people during an emergency. So here is the fastest way to find which one applies to you.

Where is the clot? Because a clot in the leg and a clot in the lungs lead to completely different studies.
How long ago did it start? Notably, every study here has a hard time window, and the shortest is 14 days.
Are you already on a blood thinner? In fact, that rules you out of the one study that uses plain aspirin.
Finally, put your name in. Then we check you against all 4 and call you the day a new one opens near you.

Of course, checking never signs you up for anything. You are only seeing where you might fit.

The 4 Blood Clot Studies Worth Knowing About Near Charlotte

Notably, only one is in Charlotte, and it is narrow. So read the rules on each before you call anybody.

The one inside Charlotte

Read the rules on this one before anything else. Notably, it only takes men having chemotherapy for one specific cancer.

Can Plain Aspirin Prevent Clots During Chemotherapy?

Wake Forest University / Drug

Men having chemotherapy for testicular or germ cell cancer are at very high risk of clots. So this gives one low dose aspirin a day for 26 weeks, to see whether that cheap pill is enough.

Mid stage, testing whether it works During chemotherapy only

Payment is not published. Notably, you supply your own aspirin.

See if you fit →

More details

Why researchers are excited: if plain aspirin works, it would protect a high risk group without the cost, injections or bleeding risk of prescription thinners.

Who this study is looking for

Men aged 18 to 70
Also, confirmed testicular or germ cell cancer at stage IS or IIA and above
Besides that, at least one high clot risk feature
Finally, you are starting standard chemotherapy, and aspirin begins within 2 weeks of it

Probably not a fit if: you have had a clot before, or you already take a blood thinner, or you have a history of stomach ulcers.

Placebo group: None at all and no comparison group. Everybody gets the real aspirin, and results are compared against past records.
How long: 26 weeks of aspirin, with outcomes tracked to 2 years.
Clinic visits: Study specific check points at 26 weeks and 2 years. Meanwhile, day to day contact rides along with the chemotherapy appointments you were already attending.
Phone calls: Not published on the public record.
Most invasive part: Blood draws and scans to check for clots. Notably, the chemotherapy is standard cancer care rather than part of the study.
Setting: Outpatient.
Where it runs: Atrium Health Wake Forest Baptist, Charlotte NC 28204.
Drive from Charlotte: This one is in Charlotte itself, off Randolph Road.
Read this first: this is only for men on chemotherapy for one specific cancer. So it is not a general blood clot study, and most people reading this page will not fit it.
Full study record: View on ClinicalTrials.gov →

For a clot in the leg or pelvis

In fact, this is the closest general clot study to Charlotte. However, it has closed sites elsewhere, so call before you drive.

Pulling the Clot Out, or Blood Thinners Alone

Inari Medical / Device

People with a large clot in the pelvis or thigh veins either get it pulled out with a catheter plus blood thinners, or they get blood thinners alone. Then leg symptoms are measured at 6 months.

Randomised device study No placebo

Est. $300 or so, across about 3 visits

Get on the list →

More details

Why researchers are excited: this is the randomised test the field has demanded, on whether pulling a clot out prevents lasting leg damage.

Who this study is looking for

Adults 18 and older
Also, A clot in the deep veins of the pelvis or thigh
Besides that, symptoms started within the last 12 weeks
Finally, significant leg symptoms on a standard score

Probably not a fit if: you have clots in both legs, or a filter already in place, or a stent already in that vein.

Placebo group: No dummy and no fake procedure. The comparison group gets real, guideline standard blood thinners.
How long: 6 months for the main result.
Clinic visits: Only 3, and the record is unusually clean. Baseline and the procedure, then 10 days, then 180 days.
Phone calls: Not published on the public record.
Most invasive part: A catheter into the leg vein to pull the clot out.
Setting: Outpatient.
Where it runs: Spartanburg Medical Center, Spartanburg SC 29303.
Drive from Charlotte: Spartanburg is about 75 miles southwest, so roughly 80 minutes on I-85.
Check before you drive: this study has closed many sites nationally. So confirm Spartanburg is still open before making the trip.
Full study record: View on ClinicalTrials.gov →

For a clot in the lungs, enrolled in an emergency

Nobody plans for these. Still, knowing they exist means you can ask about them in the hospital.

Vacuuming a Clot Out of the Lung Arteries

Penumbra / Observational

People with a clot in the lungs that is straining the heart have it vacuumed out through a catheter. Then researchers follow their heart strain, breathing and walking for a year.

Observational, device already in use Emergency only

Payment is not published. Notably, enrolment happens in an emergency.

Get on the list →

More details

Why researchers are excited: unusually, it tracks how people actually feel a year later rather than just what the scan shows.

Who this study is looking for

Adults 18 and older
Also, lung clot symptoms for 14 days or less
Besides that, A scan shows the right side of the heart is strained
Finally, this device is used as the first treatment

Probably not a fit if: you cannot take blood thinners, or you have advanced cancer, or you are already on life support.

Placebo group: None at all. Everybody gets the real treatment, because nothing is randomised.
How long: 365 days.
Clinic visits: About 4 or 5. The procedure, 48 hours, 30 days, 90 days, then a safety check at a year.
Phone calls: Not published on the public record.
Most invasive part: A catheter passed through a vein into the lung arteries to suck the clot out.
Setting: Outpatient.
Where it runs: NC Heart and Vascular Research, Raleigh NC 27607.
Worth knowing: this device has to be the first treatment used. So if you have already been given clot busting drugs, you are out.
Full study record: View on ClinicalTrials.gov →

Treating a Lung Clot Without the Intensive Care Stay

Thrombolex / Device

A basket shaped catheter sprays a clot busting drug into the lung arteries through 48 tiny holes. So the design avoids both an intensive care stay and being tethered to a slow drip overnight.

Device study Emergency only

Payment is not published. However, both follow ups are by phone.

Get on the list →

More details

Why researchers are excited: it tests something people actually care about, which is getting treated without the intensive care unit.

Who this study is looking for

Lung clot symptoms for 15 days or less
Also, A blockage in at least one major lung artery on a scan
Besides that, diagnosed as intermediate risk
Finally, the right side of the heart shows strain

Probably not a fit if: you had major surgery within 10 days, or a past stroke with lasting weakness, or you needed CPR this admission.

Placebo group: None at all. Everybody gets the real device and drug.
How long: 30 days.
Clinic visits: 1 in person plus 2 phone calls, and the record says so plainly. The procedure, then phone follow ups at 7 and 30 days.
Phone calls: Yes, and both follow ups are explicitly by phone.
Most invasive part: A catheter into the lung arteries plus a clot busting drug.
Setting: Outpatient.
Where it runs: Emory University, Atlanta GA 30308.
Worth knowing: the whole study hangs on one measure at 7 days, and no other outcomes are published at all.
Full study record: View on ClinicalTrials.gov →

Not sure which one fits you?

First, answer a few quick health questions. Then we check you against all 4 studies. Finally, we call you when a new one opens near Charlotte. No account, no paperwork.

See if I may fit one of these studies →

✓ Takes just a few minutes✓ No cost, no obligation✓ You are never enrolled by checking

Why Blood Clot Research Matters Here in Charlotte

The clot nobody saw coming

A calf swells up and feels tight and warm, and it gets blamed on a strain or a long drive. Then a week later comes chest pain, or breathlessness that arrives out of nowhere. Meanwhile, the trigger is usually something ordinary. A hospital stay, an operation, a long flight, cancer treatment, or a pregnancy. Also, the danger is that a piece breaks loose and travels to the lungs, which can turn serious within hours.

What is actually being studied here

Gastonia, Rock Hill, Monroe, Concord, Kannapolis. Clots turn up after operations, hospital stays and cancer treatment across all of them. In fact, Charlotte does a great deal of joint replacement and cancer care, and both raise clot risk sharply. However, only one clot study is enrolling inside the metro, and it is limited to men having chemotherapy. So the honest picture is a strong care network with a thin research map.

So why is there so little to join?

Most clot care is emergency care. People arrive at the emergency room, get treated fast, and go home. So there is rarely a calm moment to discuss a study.
The windows are measured in days. Two of these take you only within 14 or 15 days of symptoms starting. Meanwhile, most people do not know research exists until later.
The device trials sit at big centres. Raleigh and Atlanta carry the two lung clot studies. Also, the nearest leg clot study is at Spartanburg.
Sponsors start where they already have sites. A company opens where it has run studies before. So a metro can be skipped for years for no medical reason.
The rules are narrow. Many of these studies want a very specific patient. However, that cuts both ways, because being unusual sometimes opens a door.

Research is a care option, not a last resort

There is a saying in medicine that research is a care option rather than a last resort. Generally, that is the honest way to think about a study. You are not giving up your own doctor. Instead, you are adding a second set of eyes. Notably, none of these four uses a dummy procedure, and the comparison group always gets real, standard treatment.

What being on the list actually gets you

This is a directory, not a clinic. So being on the list is simple and it costs nothing.

What you actually get

A call from us the day a new study opens near you
The clinic name and number, so you call them yourself
A check against every other study on our list, not just this one
No cost, and no insurance needed
Roughly $100 a visit for your time, once you are in a study
You are never enrolled by checking

Add it up. There is very little open for this in either city, and we would rather say so than pad the page out. However, the field is moving on three fronts at once, and one recent trial overturned what doctors believed about lasting leg damage. So the useful thing this page can do is make sure you hear the moment a study opens near you.

What Is Actually Being Tested for Blood Clots

Three shifts, and one of them overturned an assumption.

Two Names for the Same Problem

A clot in a deep vein, usually the leg or pelvis, causes swelling, pain and heaviness. If a piece breaks off and travels to the lungs, it blocks blood flow there and can be fatal within hours. So they are the same illness at two stages. Also, both are triggered by things that slow blood down, such as surgery, hospital stays, long stillness, cancer and pregnancy.

The Old Approach Left Damage Behind

Standard treatment has been the same for decades. Blood thinners stop the clot growing while your body slowly dissolves it. However, that leaves up to half of people with lasting leg damage. So the first big shift is mechanical. Rather than waiting, doctors thread a catheter in and physically pull the clot out. Notably, one study here is the randomised test of whether that actually prevents the long term damage.

The Damage May Not Be Permanent

The second shift overturned something the field had assumed. A recent trial showed that even severe, established leg damage after a clot can be improved with vein stenting. As Suresh Vedantham, who led it, put it, these people have suffered in silence because few doctors are aware of the complication or know how to treat it. So if you were told years ago that nothing more could be done, that advice may now be out of date.

Safer Prevention

The third shift is about stopping clots without causing bleeding. A new class of drug blocks a different clotting factor, on the theory that you can have one without the other. Meanwhile, researchers are also asking whether cheap familiar aspirin is enough for specific very high risk groups. In fact, the one study near Charlotte tests exactly that in men having chemotherapy.

Why the List Here Is Short

We will be straight with you. There is almost nothing open for this in either city. The one Charlotte study is only for men on chemotherapy for one specific cancer, so it will not fit most readers. Also, the closest general clot study is in Spartanburg, and that trial has closed many of its sites. So this page is mostly a waiting list, and we would rather say that than pad it out.

Research Sites Near Charlotte

Notably, only one of them runs a clot study today. But sites add new studies all the time, so it is worth knowing what sits near you.

Atrium Health

Multiple Charlotte locations / 161+ active studies

Crohn’s, Heart Failure, COPD, Dementia, Type 2 Diabetes, Hypertension

Charlotte’s biggest health system. It is tied to Wake Forest University School of Medicine. Also, it runs far more trials than anyone else nearby.

Visit Website →

American Health Research Network

Ballantyne, NC 28277 / 25 to 30+ active studies

Asthma, COPD, Chronic Cough, Type 2 Diabetes

Led by Dr. Selwyn Spangenthal. It is the biggest private lung research group in Charlotte. Specifically, it has 4 offices: Charlotte, Rock Hill, Lake Norman, and Charleston.

Visit Website →

Monroe Biomedical Research

Monroe, NC / 17+ active studies

Asthma, COPD, Hypertension, Obesity, Ulcerative Colitis

Notably, one of the 5 busiest research sites in the country. Its 6,300 sq ft space can host overnight stays. It is also an SCRS Global Impact Partner.

Visit Website →

Clinical Research of Gastonia

Gastonia, NC / 11+ active studies

Asthma, COPD, Chronic Cough, Idiopathic Hypersomnia

Led by Dr. Anup Banerjee. Its 3,500 sq ft space sits next to CaroMont Regional Medical Center. Also, it has been running for over 10 years.

Visit Website →

OnSite Clinical Solutions

Ballantyne, NC 28277 / 10+ active studies

Ulcerative Colitis, Crohn’s, COPD, Heart Failure, Atopic Dermatitis

It works with Charlotte doctors in heart, gut, skin, nerve, and joint care. Besides, it runs studies from Phase I through Phase IV.

Visit Website →

Flourish Research

Matthews, NC 28105 / 4+ active studies

Alzheimer’s Disease, Early Alzheimer’s, Alzheimer’s-Related Psychosis

Led by Dr. M. Reza Bolouri. He has 20+ years in Alzheimer’s research. The site is an Alzheimer’s Center of Excellence. In fact, its network has finished 5,500+ trials.

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New Hope Clinical Research

SouthPark, NC 28211 / 4+ active studies

Major Depression, Schizophrenia, Bipolar Disorder

Led by Dr. Kurian Abraham. It runs Phase I through IV studies and has 30 beds for overnight stays. Its last FDA audit came back clean. Also, it has finished 200+ brain studies.

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Queen City Clinical Research

SouthPark, NC 28211 / 2+ active studies

Chronic Pain, Chronic Migraine, Osteoarthritis

Led by Dr. Leonardo Kapural, a former Cleveland Clinic professor. Notably, he has written 200+ journal articles. On top of that, many call this the biggest pain research site in the country.

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Novant Health

Multiple Charlotte locations / Several active studies

Cardiovascular Disease, Obesity, Hypertension

One of the biggest health systems in the Carolinas. Its Heart and Vascular Institute runs heart studies and sees a lot of patients.

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DLVSC

4 Charlotte-area offices / 1+ active studies

Eczema, Psoriasis, Rosacea

Led by Dr. Gilly Munavalli. This award-winning skin practice owns 50+ FDA-approved lasers and devices. Also, it has its own research team.

Visit Website →

DelRicht Research

South Charlotte, NC 28210 / 1+ active studies

Bipolar Disorder, Bipolar Depression

Part of a national network of mental health research sites. Currently, it runs the azetukalner bipolar depression trial in Charlotte. Previously, it ran other mental health studies.

Visit Website →

TMS of the Carolinas

South Charlotte, NC 28210 / 1+ active studies

Major Depression, Treatment-Resistant Depression

A specialty site for brain stimulation care. It runs the fast TMS study that packs 6 weeks into 2.

Visit Website →

What to Expect in a Blood Clot Study

New to studies? Here is how one works, step by step.

Prescreening

First comes a short phone call or online form. Also, it takes about 10 to 15 minutes. The staff check whether you might fit. Then they tell you what is open.

Screening Visit

Next the clinic runs the tests that decide it, which usually means blood work. Also, they go through the consent form line by line, and you can bring somebody with you.

Treatment Period

Then the study begins. So you take the study drug or the placebo on the agreed schedule. Meanwhile, your own doctor keeps managing everything else.

Follow-Up

Finally, there is a check in period at the end. Also, your own doctor gets the results, and you can stop at any point without affecting your care.

Blood Clot Trial FAQs

Real answers about DVT and pulmonary embolism studies near Charlotte NC.

Is there a blood clot study near Charlotte?

Yes, one, and it is in Charlotte itself. However, its rules are narrow, because it only takes men having chemotherapy for testicular or germ cell cancer. Also, three more studies sit within a drive, at Spartanburg, Raleigh and Atlanta. So most readers here will be waiting rather than joining, and we would rather say that upfront.

What is the difference between a leg clot and a lung clot?

They are the same illness at two stages. A clot forms in a deep vein, usually the leg or pelvis, and causes swelling, pain and heaviness. If a piece breaks off it travels to the lungs and blocks blood flow there, which can be fatal within hours. So the studies here are split between the two, and where your clot is decides which ones you can join.

Will I be taken off my blood thinner?

No, and that is worth saying plainly. Every study here keeps standard treatment in place for everybody. In the leg clot study the comparison group gets real, guideline standard blood thinners, not a dummy. So no study on this page asks you to go without treatment.

Is there a placebo in any of these?

No dummy procedure in any of the four. The lung clot studies give everybody the real device. The leg clot study compares pulling the clot out against real blood thinners. Also, the aspirin study gives the real aspirin to everybody who joins.

Can lasting leg damage after a clot be treated?

This is the part that changed recently, and it matters. A recent trial showed that even severe, established leg damage after a clot can be improved with vein stenting. As Suresh Vedantham, who led it, put it, these people have suffered in silence because few doctors are aware of the complication. So if you were told years ago that nothing more could be done, that advice may now be out of date.

Why are the time windows so short?

Because a fresh clot behaves differently from an old one. A recent clot is soft enough to pull out or dissolve, while an older one has hardened and stuck to the vein wall. So the studies here cut off at 14 days, 15 days or 12 weeks depending on the design. In short, if a clot has just been found, that is the moment to ask rather than months later.

What should I ask in the hospital?

Ask whether any research study is open for what you have, and ask it early. Two of these studies enroll people during an emergency, so the window can be hours rather than days. Also, ask your doctor to note that you are interested even if nothing is open right then. Meanwhile, you can put your name on our list so we call you if one opens later.

Does it cost anything to be on the list?

No. There is no cost, and no insurance is needed. Tether is a nonprofit list, so we do not run studies and we are not paid to send you anywhere. Also, being on the list never enrolls you in anything. You would always call the clinic yourself.

How can I lower my risk of another clot?

Your own doctor decides how long you stay on a blood thinner, and that is the single biggest factor. Beyond that, move your legs on long trips, stand up regularly, and stay well hydrated. Also, tell any surgeon about your clot history before an operation, because prevention gets planned around it. Meanwhile, sudden breathlessness or chest pain is an emergency rather than something to sleep on.

Where can I get clot care near Charlotte NC?

Generally, Atrium Health Sanger Heart and Vascular Institute and Novant Health both run vascular clinics across the metro. Also, ask for a vascular specialist rather than general care if you have lasting leg swelling after a clot. Your own doctor can refer you. Meanwhile, sudden breathlessness or chest pain is an emergency, so call 911 rather than booking an appointment.

Ready to Explore a Study?

Get on the list, or just reach out to our Charlotte team. No pressure. Also, no sales pitch.

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← Back to All Clinical Trials

Sources

Study details and per-site recruiting status verified against ClinicalTrials.gov on August 15, 2026. On that date one blood clot study was enrolling in the Charlotte metro and none in the Columbia metro. Study availability and criteria change; the research clinic confirms everything before you enroll.

Tell me when a blood clot study opens near Charlotte →