CHARLOTTE, NC
Eczema Clinical Trials
2 studies are enrolling for eczema near Charlotte NC right now. Notably, one of them has no dummy group at all, because both of its groups get an approved drug. You may be compensated for your time, and no insurance is needed.
2
Open Near Charlotte
1
With No Dummy
+/- $100
Per Visit
New here? Read how this page works
First, three numbers decide which of these will take you, and most people have never been given any of them. So here is the order to work through.
- Ask your dermatologist for your EASI score. Because studies gate on it, and most want 16 or more, though one here accepts 12.
- Start an itch diary today. Notably, studies want your average worst itch across the week before you start, and a calm week can screen you out.
- Ask what percentage of your body is affected. In fact, most studies want at least 10 percent, and it is measured rather than estimated.
- Finally, tap the button. Then we check you against every study we track and tell you when a new one opens.
Of course, checking never signs you up for anything. You are only seeing where you might fit.
The 2 Studies Enrolling Near Charlotte Right Now
Both are open today. So check your eligibility, or read the full record on ClinicalTrials.gov.
The two studies open here
One tests a new shot against a dummy. Meanwhile, the other has no dummy at all, because both of its groups get an approved drug.
For People Dupilumab Stopped Helping
AbbVie / Approved drug comparison
This is only for people already on dupilumab and not doing well on it. It compares switching to a daily tablet against staying on the injection. Both drugs are approved and on the market. So there is no dummy anywhere in it, and you would know which you are on. Notably, the person scoring your skin does not know, which keeps the result honest.
Payment is not published.
Check eligibility →More details
Why researchers are excited: until now there was no good evidence on what to do when dupilumab stops working. Meanwhile, that decision gets made on guesswork in clinics every week.
Who this study is looking for
- Adults 18 to 63, with eczema going back at least 3 years
- Also, currently on dupilumab and not responding well after at least 4 months
- Besides that, an EASI score of 12 or more, and a severity grade of 3 or more
- Finally, at least 10 percent of your body surface affected
- Also, average daily itch of 4 or more in the week before starting
Probably not a fit if: one past bout of eczema herpeticum rules you out for good. That is a complication of having severe eczema, so it excludes some of the worst affected. Also, being 64 or over, or two past bouts of shingles.
- Placebo group: None at all. Both groups get a drug that is approved and licensed.
- How long: About 32 weeks of treatment. So expect roughly nine months end to end.
- Clinic visits: Regular clinic visits. However, the exact number is not published, and the record warns of a heavier load than ordinary care.
- Phone calls: Not published on the public record.
- Most invasive part: Either a daily tablet or an injection every other week. Also, regular blood tests, a TB test at screening and a daily itch diary.
- Setting: Outpatient.
- Where it runs: Piedmont Plastic Surgery and Dermatology, Huntersville NC 28078; Advanced Dermatology and Cosmetic Surgery, Spartanburg SC 29307.
- Drive from Charlotte: Huntersville is about 20 to 30 minutes north on I-77, outside rush hour.
- You must currently be on dupilumab to join. If you came off it already, this one is closed to you. So ask before you stop anything.
- Full study record: View on ClinicalTrials.gov →
A Shot Aimed at an Immune Switch
Inmagene / Mid stage injection
IMG-007 is a lab made antibody given as a shot under the skin. It targets a switch on immune cells called OX40 and turns it down. Notably, it calms those cells rather than killing them off. The hope is that each dose keeps working for a long time. So it is built for infrequent dosing rather than weekly injections.
Payment is not published.
Check eligibility →More details
Why researchers are excited: this target has produced real results for other companies, and one rival programme was stopped while this one continues. Also, a long acting shot would mean far fewer injections.
Who this study is looking for
- Adults 18 to 74, with moderate to severe eczema
- Also, an EASI score of 16 or more, and a severity grade of 3 or more
- Besides that, at least 10 percent of your body surface affected
- Finally, average itch of 4 or more out of 10 across the week before starting
- Also, creams did not work well enough, or were not advisable for you
Probably not a fit if: being 75 or older rules you out. That upper age cap is the most surprising thing here. Also, hepatitis B or C, HIV, or current or past untreated TB.
- Placebo group: Yes. Several dose levels are tested against a dummy, and the split is not published.
- How long: Dosing is assessed up to 48 weeks. However, the main read comes at week 24.
- Clinic visits: Not published on the public record.
- Phone calls: Not published on the public record.
- Most invasive part: Injections under the skin, plus a daily itch diary. Also, a full skin check at every visit and blood tests.
- Setting: Outpatient.
- Where it runs: Inmagene study site, Charlotte NC 28277.
- Drive from Charlotte: This one is in south Charlotte, off Providence Road.
- The itch diary is a real gate. A calm week can screen you out even with severe skin.
- Full study record: View on ClinicalTrials.gov →
Not sure which one fits you?
First, answer a few quick health questions. Then we check you against both at once. Also, no account and no paperwork.
See if I may fit one of these studies →What Is Actually Changing in Eczema
Ten treatments were approved in nine years, and the newest question is what to do when one stops working.
Two Things Are Going Wrong At Once
Think of skin as a brick wall. In eczema the mortar between the bricks is leaky, so water gets out and irritants get in. Meanwhile, the immune system underneath is set to overreact to what does get in. So treating only one of the two rarely settles it.
It Looks Different on Darker Skin
The classic picture people are taught is red and scaly. However, on brown and black skin it more often looks grey, purple or dark brown, and it can appear as small bumps. So it gets missed, or named as something else entirely. In fact, that is a documented reason people wait longer for the right diagnosis.
EASI Is the Number That Opens Doors
EASI runs from 0 to 72 and a doctor scores it by looking at four body areas. Most studies want 16 or more to let you in. Notably, one study on this page lowers that to 12, because its group is already partly controlled. So ask for your EASI number in writing rather than a description.
The Severity Grade Has a Hidden Rule
The other score is a 0 to 4 snapshot of how bad the skin is overall. Success usually means reaching 0 or 1, but there is a catch. You must also drop by at least two points. So going from 3 to 1 counts, while going from 2 to 1 does not, which surprises almost everybody.
The Itch Score Is Its Own Gate
Studies ask you to rate your worst itch each day from 0 to 10. Most want an average of 4 or more across the week before you start. However, that means a calm week can screen you out even if your eczema is severe. So keep the diary honestly rather than optimistically.
Dupilumab Opened the Door in 2017
It was the first targeted injection for eczema, and it was extended down to babies of six months in 2022. So it changed what was possible after decades of steroids alone. Meanwhile, it does not work for everyone, and it stops working for some. In fact, that gap is exactly what one study on this page is built around.
Then Came the Tablets
Upadacitinib and abrocitinib were both approved for eczema in January 2022. They are daily tablets that block several inflammation signals through one enzyme. So they work fast, and they suit people who dislike needles. However, they carry a boxed warning, which is why studies of them cap the age at 63 or 65.
Where That Warning Actually Came From
The warning traces back to a safety study in rheumatoid arthritis, not in eczema. That study looked at people over 50 who already had a heart risk factor. So the finding is real, but the group it came from is not the same as a young person with eczema. Notably, that is worth discussing rather than accepting as settled.
Newer Creams Are Not Steroids
Ruxolitinib cream arrived in 2021, then roflumilast and tapinarof creams in 2024. So there are now non steroid options for milder disease and for delicate areas like the face. Meanwhile, that matters most for people who have been told to limit steroid use. Generally, a dermatologist can walk you through which fits where.
Eczema Help Near You
Ask a dermatologist for your EASI score, your severity grade and your body surface percentage. Also, start an itch diary now, because studies want the week before you start. Finally, ask what happens to your current treatment during a study. Meanwhile, your own doctor can refer you.
Research Sites Near Charlotte
Two research sites carry these studies, in south Charlotte and at Huntersville. But sites add new studies all the time, so it is worth knowing what sits near you.
Atrium Health
Multiple Charlotte locations / 161+ active studies
Crohn’s, Heart Failure, COPD, Dementia, Type 2 Diabetes, Hypertension
Charlotte’s biggest health system. It is tied to Wake Forest University School of Medicine. Also, it runs far more trials than anyone else nearby.
Visit Website →
American Health Research Network
Ballantyne, NC 28277 / 25 to 30+ active studies
Asthma, COPD, Chronic Cough, Type 2 Diabetes
Led by Dr. Selwyn Spangenthal. It is the biggest private lung research group in Charlotte. Specifically, it has 4 offices: Charlotte, Rock Hill, Lake Norman, and Charleston.
Visit Website →
Monroe Biomedical Research
Monroe, NC / 17+ active studies
Asthma, COPD, Hypertension, Obesity, Ulcerative Colitis
Notably, one of the 5 busiest research sites in the country. Its 6,300 sq ft space can host overnight stays. It is also an SCRS Global Impact Partner.
Visit Website →
Clinical Research of Gastonia
Gastonia, NC / 11+ active studies
Asthma, COPD, Chronic Cough, Idiopathic Hypersomnia
Led by Dr. Anup Banerjee. Its 3,500 sq ft space sits next to CaroMont Regional Medical Center. Also, it has been running for over 10 years.
Visit Website →
OnSite Clinical Solutions
Ballantyne, NC 28277 / 10+ active studies
Ulcerative Colitis, Crohn’s, COPD, Heart Failure, Atopic Dermatitis
It works with Charlotte doctors in heart, gut, skin, nerve, and joint care. Besides, it runs studies from Phase I through Phase IV.
Visit Website →
Flourish Research
Matthews, NC 28105 / 4+ active studies
Alzheimer’s Disease, Early Alzheimer’s, Alzheimer’s-Related Psychosis
Led by Dr. M. Reza Bolouri. He has 20+ years in Alzheimer’s research. The site is an Alzheimer’s Center of Excellence. In fact, its network has finished 5,500+ trials.
Visit Website →
New Hope Clinical Research
SouthPark, NC 28211 / 4+ active studies
Major Depression, Schizophrenia, Bipolar Disorder
Led by Dr. Kurian Abraham. It runs Phase I through IV studies and has 30 beds for overnight stays. Its last FDA audit came back clean. Also, it has finished 200+ brain studies.
Visit Website →
Queen City Clinical Research
SouthPark, NC 28211 / 2+ active studies
Chronic Pain, Chronic Migraine, Osteoarthritis
Led by Dr. Leonardo Kapural, a former Cleveland Clinic professor. Notably, he has written 200+ journal articles. On top of that, many call this the biggest pain research site in the country.
Visit Website →
Novant Health
Multiple Charlotte locations / Several active studies
Cardiovascular Disease, Obesity, Hypertension
One of the biggest health systems in the Carolinas. Its Heart and Vascular Institute runs heart studies and sees a lot of patients.
Visit Website →
DLVSC
4 Charlotte-area offices / 1+ active studies
Eczema, Psoriasis, Rosacea
Led by Dr. Gilly Munavalli. This award-winning skin practice owns 50+ FDA-approved lasers and devices. Also, it has its own research team.
Visit Website →
DelRicht Research
South Charlotte, NC 28210 / 1+ active studies
Bipolar Disorder, Bipolar Depression
Part of a national network of mental health research sites. Currently, it runs the azetukalner bipolar depression trial in Charlotte. Previously, it ran other mental health studies.
Visit Website →
TMS of the Carolinas
South Charlotte, NC 28210 / 1+ active studies
Major Depression, Treatment-Resistant Depression
A specialty site for brain stimulation care. It runs the fast TMS study that packs 6 weeks into 2.
Visit Website →What to Expect in an Eczema Study
New to studies? Here is how one works, step by step.
01
Prescreening
First comes a short phone call or online form. Also, it takes about 10 to 15 minutes. The staff check whether you might fit. Then they tell you what is open.
02
Screening Visit
Next the clinic runs the tests that decide it, which usually means blood work. Also, they go through the consent form line by line, and you can bring somebody with you.
03
Treatment Period
Then the study begins. So you take the study drug or the placebo on the agreed schedule. Meanwhile, your own doctor keeps managing everything else.
04
Follow-Up
Finally, there is a check in period at the end. Also, your own doctor gets the results, and you can stop at any point without affecting your care.
Eczema Trial FAQs
Real answers about eczema studies near Charlotte NC.
Is there a study for this near Charlotte?
Yes, two are open, one in south Charlotte and one at Huntersville. One tests a new shot against a dummy, aimed at an immune switch called OX40. Meanwhile, the other has no dummy at all, because it compares two approved drugs head to head. However, that second one is only open to people currently on dupilumab and not doing well on it.
What is an EASI score?
It is how bad your eczema is, in one number, and it runs from 0 to 72. A doctor scores four body areas for redness, thickness, scratching and thickened skin. Generally, 16 or more is the usual entry bar, though one study here accepts 12. So ask for the number in writing rather than a description.
Will I get a dummy?
It depends which study, so ask this first. One here tests a new shot against a dummy, and the split is not published. However, the other has no dummy anywhere in it, because both groups get a drug that is already approved. Also, that second one is only open to people currently on dupilumab.
Why does my itch score matter so much?
Because it is a gate, not just a measure. Studies ask you to rate your worst itch daily, and most want an average of 4 or more across the week before you start. So a calm week can screen you out even when your eczema is severe. Notably, that is why starting a diary now is worth doing.
Why do some studies stop at 63 or 74?
Different reasons for each. The tablet study caps at 63 because that drug class carries a heart related warning. Meanwhile, the injection study caps at 74 for reasons it does not publish. So if you are older than that, ask us to keep watching rather than assuming nothing will come.
Why would eczema herpeticum rule me out?
Because of infection risk, and it is genuinely frustrating. One past bout is a permanent exclusion from the tablet study. However, that complication happens because you have severe eczema in the first place. So it excludes some of the people who need options most, and it is worth naming plainly.
Does eczema look different on darker skin?
Yes, and this matters for getting diagnosed. The classic picture people are taught is red and scaly. However, on brown and black skin it more often looks grey, purple or dark brown, and it can appear as small bumps. Notably, that is a documented reason people wait longer for the right answer.
Does it cost anything to check?
No. There is no cost, and no insurance is needed. Tether is a nonprofit list, so we do not run studies and we are not paid to send you anywhere. Also, checking never enrolls anyone in anything. You would always call the clinic yourself.
Where can I get help near Charlotte NC?
Atrium Health and Novant Health both run skin services across the metro, and several private dermatology practices run research here. Also, ask for a dermatologist rather than a general clinic, because the scores studies need are theirs to give. Generally, your own doctor can refer you. Meanwhile, start an itch diary now, because studies want the week before you start.
Ready to Explore a Study?
Check your eligibility, or just reach out to our Charlotte team. No pressure. Also, no sales pitch.
← Back to All Clinical TrialsSources
- ADAPTIVE, the IMG-007 study in moderate to severe eczema, ClinicalTrials.gov NCT07037901
- SWITCH-UP, a tablet against an injection after dupilumab, ClinicalTrials.gov NCT06389136
- The follow on study for people who complete ADAPTIVE, ClinicalTrials.gov NCT07734415
- A long term safety study with Columbia sites, open only to people already enrolled, ClinicalTrials.gov NCT05492578
Study details and per-site recruiting status verified against ClinicalTrials.gov on August 16, 2026. A condition search for this on Charlotte returned zero results while one of the studies listed here had a recruiting Charlotte site; both were found only by reading every site row directly. Two further studies in this field are open only to people who already completed an earlier study, so they are not listed here as options. Study availability and criteria change; the research clinic confirms everything before you enroll.