CHARLOTTE, NC

ADHD Clinical Trials

No ADHD study is enrolling near Charlotte NC, and no adult study is open in either state. Every open option in both states is for children, and we would rather say so than pad a count. Payment is provided for eligible participants once one opens here.

0

Open Near Charlotte

0

For Adults in Either State

+/- $100

Per Visit

New here? Read how this page works

First, here is the honest picture. Nothing is open here, and nothing at all is open for adults in either Carolina. So here is how to use this page.

  1. Ask for a Vanderbilt or an ASRS by name. Because those are the forms clinics really use, and the Vanderbilt ones are free to download.
  2. Get a form from a teacher or a colleague. Also, a diagnosis needs evidence from two settings, so that form is evidence rather than paperwork.
  3. Ask whether a study would stop your medicine. In fact, one nearby study needs six medicine free weeks with even odds of a dummy.
  4. Last, tap the button. Then we keep your details on file and call you when a study opens near you.

Of course, checking never signs you up for anything. You are only seeing where you might fit.

The Nearest Studies to Charlotte

Nothing in this metro. Three run at Duke, about two hours and twenty minutes away, and all three are for children or teenagers.

The nearest three, and all are for children or teenagers

No adult study is open anywhere in either Carolina. These three run at Duke, and they differ enormously in what they ask of a family.

For Teenagers, and It Does Not Touch Medication

Duke University / Therapy study

Two non drug group programmes for teenagers, compared head to head. One teaches concrete systems, meaning planners, backpacks, tracking assignments and estimating time. The other teaches mindfulness and attention practice. Both groups get a real programme, so there is no dummy and no waiting list. Also, nothing in this study asks you to change or stop ADHD medicine.

Therapy study, 30 teenagers No dummy

Payment is not published.

Get on the list →
More details

Why researchers are excited: for a family unwilling to interrupt medicine that is working, this is the only nearby option that leaves it completely alone. Meanwhile, both arms are real treatment.

Who this study is looking for

  • Aged 13 to 17
  • Also, an existing ADHD diagnosis already in the medical record
  • Besides that, seeking treatment at the Duke ADHD programme
  • Finally, A caregiver willing to fill in forms before and after

Probably not a fit if: the study team decides case by case. Another mental health problem that gets in the way of treating ADHD can exclude you, and the exact conditions are not named. So this is one to ask about directly rather than guess.

  • Placebo group: None. Both groups get eight real sessions, and neither is a waiting list.
  • How long: Eight weeks.
  • Clinic visits: Eight sessions of ninety minutes each, about one a week. The record states that outright.
  • Phone calls: None published. Forms are completed online before and after.
  • Most invasive part: Nothing physical whatsoever. So the cost is time, travel and homework between sessions.
  • Setting: Outpatient.
  • Where it runs: Duke University, Durham NC 27705.
  • Drive from Charlotte: Durham is about 143 miles north east, so roughly two hours and twenty minutes.
  • You have to be a Duke ADHD programme patient. That means establishing care there first, which is a real step and worth knowing before you plan anything.
  • Full study record: View on ClinicalTrials.gov →

For Four and Five Year Olds Only

Supernus Pharmaceuticals / Approved drug study

This tests a non stimulant approved from age six, in children aged four and five. That is the age group where doctors have the least evidence and the most hesitation. It is one capsule a day, which can be opened and sprinkled on apple sauce. Half the children get a dummy for six weeks, so it is a straight coin flip. The nearest sites are Durham, North Charleston and Summerville.

Approved drug study, 286 children Ages 4 and 5

Payment is not published.

Get on the list →
More details

Why researchers are excited: almost nothing has been properly tested in preschoolers, so families are left guessing. Meanwhile, this is the only ADHD drug trial recruiting anywhere in North Carolina.

Who this study is looking for

  • Aged 4 years 0 months to 5 years 9 months
  • Also, A symptom score at or above the study threshold, at two separate visits
  • Besides that, rated at least moderately affected, again at both visits
  • Finally, in a structured group activity at least two days a week, such as preschool or camp
  • Also, living with the same parent or guardian for six months

Probably not a fit if: nightly melatonin rules a child out. That is a written exclusion and it quietly disqualifies a great many treated preschoolers. Also, a parent or sibling with bipolar disorder, and a body mass index above the 95th percentile or a weight below the 5th.

  • Placebo group: Yes, at even odds. Half the children get a dummy capsule for the full six weeks.
  • How long: Up to ten weeks in total, including up to four weeks of screening.
  • Clinic visits: About 5 to 7 in person. Screening and the baseline visit are named separately in the record, and week 6 is the main measure.
  • Phone calls: None published.
  • Most invasive part: A heart tracing and blood work at screening. Also a long structured interview with the parent.
  • Setting: Outpatient.
  • Where it runs: Duke University, Durham NC 27705.
  • Drive from Charlotte: Durham is about 143 miles north east, so roughly two hours and twenty minutes.
  • A medicated child comes off treatment for the whole study. That is at least seven days before starting and then the full six weeks, with even odds of a dummy. So weigh it honestly.
  • Full study record: View on ClinicalTrials.gov →

A Sleep and Body Clock Study, With No Treatment

Duke University with the NIMH / Measuring study

Many children with ADHD run on a late body clock, so their natural sleep signal arrives hours after bedtime. This measures that directly, with saliva samples in a dim room and a week of sleep tracking at home. Nothing is given and nothing is treated, so there is no dummy and nothing to react to. But one of the three visits is a long evening session. The site is at Durham.

Measuring study, 250 children Ages 6 to 9

Payment is not published.

Get on the list →
More details

Why researchers are excited: sleep is one of the biggest untreated problems in childhood ADHD and it is rarely measured properly. Meanwhile, existing stimulant treatment is not a barrier here.

Who this study is looking for

  • Aged 6 to 9
  • Also, ADHD as the main diagnosis
  • Besides that, medically healthy
  • Finally, willing to pause melatonin for the study period

Probably not a fit if: an autism diagnosis rules a child out. So does diagnosed sleep apnoea or restless legs, which is ironic given the subject. Also, any sleep medicine other than melatonin, and plans to start a stimulant during the study.

  • Placebo group: None. Nothing is given, because this only measures.
  • How long: About two weeks of active participation.
  • Clinic visits: Three visits, and the record says so outright. One is a night session of about five hours, often on a Friday.
  • Phone calls: None published.
  • Most invasive part: No needles and no drug, but eleven saliva samples across a five hour evening. Also three sensors worn every night for a week.
  • Setting: Outpatient.
  • Where it runs: Duke University Medical Center, Durham NC 27705.
  • Drive from Charlotte: Durham is about 143 miles north east, so roughly two hours and twenty minutes.
  • The night session is the whole decision. Five hours ending near midnight, two hours from Charlotte, almost certainly means an overnight stay.
  • Full study record: View on ClinicalTrials.gov →

Not sure which one fits you?

First, answer a few quick health questions. Then we keep them on file. Finally, we call you when a study opens near Charlotte. No account, no paperwork.

See if I may fit one of these studies →
✓ Takes just a few minutes✓ No cost, no obligation✓ You are never enrolled by checking

Why ADHD Research Matters Here in Charlotte

Knowing what you need to do and not being able to start

It is rarely about not caring, and almost always about not being able to begin, switch or stop. Meanwhile, the part that wears people down is the gap between what they can do and what they really get done. So the tiredness is real and rest does not fix it. In fact, many adults only look into this after a child is assessed and something sounds familiar.

What is actually being studied here

Rock Hill, Concord, Gastonia, Huntersville, Matthews, Mooresville. Nothing recruits in this metro, and every one of the twenty two towns was swept on its own. The second finding is worth its own line. There is no adult study of any kind recruiting anywhere in North or South Carolina, so every open option in both states is for children. So the nearest three all run at Duke, about two hours and twenty minutes away. But a state level search returned only one study in this state, which was wrong by a factor of three.

So why is nothing open here?

  • The research is almost all in children. New drugs are tested in adults first and then in children. Meanwhile, the current wave is the children’s half.
  • Adults are the fastest growing group diagnosed. And there is nothing open for them in either state. So the gap between need and research is very wide here.
  • These studies run at academic centres. Duke carries three of them. But that is over two hours from this metro.
  • A big study looks local and is not. One lists a Columbia South Carolina site under an open headline. Also, that row’s own status is closed.
  • State searches undercount badly. One study returned for this state, against three found by town sweeps. In fact, that is why every town gets swept.

Research is a care option, not a last resort

There is a saying in medicine that research is a care option rather than a last resort. Generally, that is the honest way to think about a study. You are not giving up your own doctor. Instead, you are adding a second set of eyes. Also, one of the nearby studies asks for no medicine change at all, so a family unwilling to interrupt treatment still has an option.

What being on the list actually gets you

This is a directory, not a clinic. So being on the list is simple and it costs nothing.

What you actually get

  • A call from us the day a new study opens near you
  • The clinic name and number, so you call them yourself
  • A check against every other study on our list, not just this one
  • No cost, and no insurance needed
  • Roughly $100 a visit for your time, once you are in a study
  • You are never enrolled by checking

So add it up. Nothing in this metro, nothing for adults anywhere in either Carolina, and three children’s studies at Duke. Meanwhile, that changes quickly and at least one adult study is due to begin with no sites announced yet. So the useful thing to do today is get a Vanderbilt or an ASRS and ask your own clinic whether they have been approached as a site.

What Is Actually Happening in ADHD Care

The research is almost entirely in children, while the fastest growing group being diagnosed is adults.

Adult ADHD Is Real and Routinely Missed

It does not stop at eighteen, and in women it far more often looks like disorganisation, forgetfulness and constant overwhelm rather than visible restlessness. So a lot of women are diagnosed in their thirties or forties, often after their own child is assessed. Meanwhile, being called spacey or a daydreamer as a girl is a reason to ask, not a reason to dismiss.

A Proper Adult Diagnosis Looks at Childhood

This is a condition that starts early, so an assessment has to find signs before about age twelve. Bring old school reports, and ask a parent or older sibling what you were like at eight. So that step is what separates ADHD from anxiety, depression, poor sleep and thyroid problems. Also, a clinic that diagnoses you in fifteen minutes without asking about childhood has skipped it.

Stimulants and Non Stimulants Are Different Tools

Stimulants often work within an hour of the right dose and wear off the same day. Non stimulants take two to six weeks to show their full effect and work around the clock. So judging a non stimulant after five days is not a fair trial of it. In fact, the only ADHD drug study recruiting anywhere in North Carolina is testing a non stimulant.

Non Stimulants Are Not a Consolation Prize

They are often the better first choice where there is a substance use history. The same holds where stimulants caused anxiety or sleep problems. It holds again where a family prefers a drug that is not controlled. So ask what a non stimulant trial would look like and how long before you would know. Meanwhile, that question is asked far less often than it should be.

The Stimulant Shortage Is Structural

These drugs sit under yearly production quotas. Also, you cannot usually move a prescription between pharmacies the way you can with ordinary ones. So call ahead to check stock before the prescription is sent, because an unfilled one can strand you. Also, ask whether a different formulation is in stock, or whether a non stimulant could bridge the gap. In general, tell the prescriber’s office rather than simply waiting.

Ask for the Rating Scales by Name

For adults the names are ASRS, AISRS and ACDS. For children they are the Vanderbilt scales, the ADHD Rating Scale and the Conners. So saying can we do a Vanderbilt with a teacher form moves an appointment forward faster than anything else. In fact, the Vanderbilt forms are free and downloadable.

A Diagnosis Needs Two Settings

ADHD is defined by difficulty in more than one environment, so a teacher form is evidence rather than paperwork. For an adult that means work or study as well as home. So if no one has asked for outside information, the assessment is incomplete. Meanwhile, one study near Charleston exists precisely because those teacher forms so often never come back.

Ask Whether a Study Stops Your Medication

This is where families are most often blindsided. The preschool drug study asks you to stop ADHD medicine at least a week before and to stay off it for the full six weeks, with even odds of a dummy. By contrast the teenage skills study asks for no medicine change at all. So ask it in those exact words on the first call.

Ordinary Things Disqualify People

Nightly melatonin excludes a child from the preschool study, and that is extremely common. A parent or sibling with bipolar disorder excludes them too. A single course of an antipsychotic years ago permanently excludes a child from the study near Charleston. So read the boring criteria and volunteer the full medicine history, supplements included.

Nothing Today Is Not Nothing Ever

Nothing at all is recruiting in either metro right now, and no adult ADHD study is recruiting anywhere in either Carolina. That is the truth and it saves wasted phone calls. But it changes fast, and at least one adult study is due to begin enrolling with no sites announced yet. Meanwhile, ask your own clinician whether their practice has been approached as a site.

ADHD Help Near You

Ask for a Vanderbilt or an ASRS by name, and get a form from a teacher or a colleague. Also, ask whether a study would require stopping medicine, before anything else. Last, if you are an adult, ask about childhood evidence, since that is the step most often skipped. Meanwhile, join the list and we will call you when something opens near you.

Research Sites Near Charlotte

Nothing runs in this metro for ADHD today, while the nearest sites sit at Duke in Durham. But sites add new studies all the time, so it is worth being on the list.

Atrium Health

Multiple Charlotte locations / 161+ active studies

Crohn’s, Heart Failure, COPD, Dementia, Type 2 Diabetes, Hypertension

Charlotte’s biggest health system. It is tied to Wake Forest University School of Medicine. Also, it runs far more trials than anyone else nearby.

Visit Website →

American Health Research Network

Ballantyne, NC 28277 / 25 to 30+ active studies

Asthma, COPD, Chronic Cough, Type 2 Diabetes

Led by Dr. Selwyn Spangenthal. It is the biggest private lung research group in Charlotte. Specifically, it has 4 offices: Charlotte, Rock Hill, Lake Norman, and Charleston.

Visit Website →

Monroe Biomedical Research

Monroe, NC / 17+ active studies

Asthma, COPD, Hypertension, Obesity, Ulcerative Colitis

Notably, one of the 5 busiest research sites in the country. Its 6,300 sq ft space can host overnight stays. It is also an SCRS Global Impact Partner.

Visit Website →

Clinical Research of Gastonia

Gastonia, NC / 11+ active studies

Asthma, COPD, Chronic Cough, Idiopathic Hypersomnia

Led by Dr. Anup Banerjee. Its 3,500 sq ft space sits next to CaroMont Regional Medical Center. Also, it has been running for over 10 years.

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OnSite Clinical Solutions

Ballantyne, NC 28277 / 10+ active studies

Ulcerative Colitis, Crohn’s, COPD, Heart Failure, Atopic Dermatitis

It works with Charlotte doctors in heart, gut, skin, nerve, and joint care. Besides, it runs studies from Phase I through Phase IV.

Visit Website →

Flourish Research

Matthews, NC 28105 / 4+ active studies

Alzheimer’s Disease, Early Alzheimer’s, Alzheimer’s-Related Psychosis

Led by Dr. M. Reza Bolouri. He has 20+ years in Alzheimer’s research. The site is an Alzheimer’s Center of Excellence. In fact, its network has finished 5,500+ trials.

Visit Website →

New Hope Clinical Research

SouthPark, NC 28211 / 4+ active studies

Major Depression, Schizophrenia, Bipolar Disorder

Led by Dr. Kurian Abraham. It runs Phase I through IV studies and has 30 beds for overnight stays. Its last FDA audit came back clean. Also, it has finished 200+ brain studies.

Visit Website →

Queen City Clinical Research

SouthPark, NC 28211 / 2+ active studies

Chronic Pain, Chronic Migraine, Osteoarthritis

Led by Dr. Leonardo Kapural, a former Cleveland Clinic professor. Notably, he has written 200+ journal articles. On top of that, many call this the biggest pain research site in the country.

Visit Website →

Novant Health

Multiple Charlotte locations / Several active studies

Cardiovascular Disease, Obesity, Hypertension

One of the biggest health systems in the Carolinas. Its Heart and Vascular Institute runs heart studies and sees a lot of patients.

Visit Website →

DLVSC

4 Charlotte-area offices / 1+ active studies

Eczema, Psoriasis, Rosacea

Led by Dr. Gilly Munavalli. This award-winning skin practice owns 50+ FDA-approved lasers and devices. Also, it has its own research team.

Visit Website →

DelRicht Research

South Charlotte, NC 28210 / 1+ active studies

Bipolar Disorder, Bipolar Depression

Part of a national network of mental health research sites. Currently, it runs the azetukalner bipolar depression trial in Charlotte. Previously, it ran other mental health studies.

Visit Website →

TMS of the Carolinas

South Charlotte, NC 28210 / 1+ active studies

Major Depression, Treatment-Resistant Depression

A specialty site for brain stimulation care. It runs the fast TMS study that packs 6 weeks into 2.

Visit Website →

What to Expect in an ADHD Study

New to studies? Here is how one works, step by step.

01

Prescreening

First comes a short phone call or online form. Also, it takes about 10 to 15 minutes. The staff check whether you might fit. Then they tell you what is open.

02

Screening Visit

Next the clinic runs the tests that decide it, which usually means blood work. Also, they go through the consent form line by line, and you can bring somebody with you.

03

Treatment Period

Then the study begins. So you take the study drug or the placebo on the agreed schedule. Meanwhile, your own doctor keeps managing everything else.

04

Follow-Up

Finally, there is a check in period at the end. Also, your own doctor gets the results, and you can stop at any point without affecting your care.

ADHD Trial FAQs

Real answers about adhd studies near Charlotte NC.

Is there a study for this near Charlotte?

No, and we will not pretend otherwise. Every one of the twenty two towns in this metro was swept on its own. There is also no adult study of any kind recruiting anywhere in North or South Carolina, which is worth saying outright. But three run at Duke about two hours and twenty minutes away, and all three are for children or teenagers. Also, one of those asks for no medicine change at all.

Is adult ADHD real?

Yes, and it is missed constantly, especially in women. In girls it far more often looks like disorganisation, forgetfulness and constant overwhelm rather than restlessness. So many women are diagnosed in their thirties or forties, often after their own child is assessed. Meanwhile, being called a daydreamer as a girl is a reason to ask, not a reason to dismiss.

Why do they ask about my childhood?

Because this starts early, so an assessment has to find signs before about age twelve. Bring old school reports, and ask a parent or older sibling what you were like at eight. So that step is what separates it from anxiety, low mood, poor sleep and thyroid problems. Also, a clinic that diagnoses you in fifteen minutes without asking has skipped it.

What is the difference between the two kinds of drug?

Stimulants often work within an hour of the right dose and wear off the same day. The other kind takes two to six weeks to show its full effect and works around the clock. So judging the second kind after five days is not a fair trial of it. In fact, the only drug study recruiting in North Carolina is testing that second kind.

Why can I not get my prescription filled?

These drugs sit under yearly production limits, and prescriptions cannot be moved between pharmacies easily. So call ahead to check stock before the prescription is sent. Also, ask whether a different form is in stock, or whether a non stimulant could bridge the gap. Meanwhile, tell the prescriber’s office rather than simply waiting.

What are the rating scales called?

For adults, the ASRS, the AISRS and the ACDS. For children, the Vanderbilt scales and the ADHD Rating Scale. So saying can we do a Vanderbilt with a teacher form moves an appointment along faster than anything else. Also, the Vanderbilt forms are free and you can download them. Also, the teacher form is evidence rather than paperwork.

Would a study stop my medicine?

Sometimes, and this is where families get blindsided. The preschool drug study asks you to stop at least a week before and to stay off for the whole six weeks. By contrast the teenage skills study asks for no medicine change at all. So ask it in those exact words on the first call.

What ordinary things disqualify people?

Nightly melatonin rules a child out of the preschool study, and that is extremely common. So does a parent or sibling with bipolar disorder, or a weight outside a set range. One study near Charleston permanently excludes a child who ever had a course of an antipsychotic. So volunteer the full medicine history including supplements.

Does it cost anything to check?

No. There is no cost, and no insurance is needed. Tether is a nonprofit list, so we do not run studies and we are not paid to send you anywhere. Also, checking never enrolls anyone in anything. You would always call the clinic yourself.

Where can I get help near Charlotte?

Atrium Health and Novant Health both run behavioural health services across the metro. Also, ask for a Vanderbilt or an ASRS by name, and get a form from a teacher or a colleague. In general, an adult assessment should ask about your childhood, and one that does not has skipped a step. Meanwhile, ask your own clinic whether they have been approached about hosting a study.

Ready to Explore a Study?

Check your eligibility, or just reach out to our Charlotte team. No pressure. Also, no sales pitch.

← Back to All Clinical Trials

Sources

Study details and per-site recruiting status verified against ClinicalTrials.gov on August 17, 2026, with all 22 Charlotte metro towns and all 14 Columbia metro towns swept individually. Two findings are worth stating outright. Nothing is open in either metro. Also, no adult study of any kind is open in either state. Every open option is for children. The most misleading record here reads as recruiting and lists a real University of South Carolina site in Columbia. But that row’s own status is completed. So checking the state field and stopping there would give the wrong answer. A state level search returned one study in North Carolina and two in South Carolina. Both answers were wrong. City sweeps found roughly three times as many. Study openings and criteria change. The research clinic confirms it all before you enroll.

Tell me when an ADHD study opens near Charlotte →