CHARLOTTE, NC
ADHD Clinical Trials
No ADHD study is enrolling near Charlotte NC, and no adult study is open in either state. Every open option in both states is for children, and we would rather say so than pad a count. Payment is provided for eligible participants once one opens here.
0
Open Near Charlotte
0
For Adults in Either State
+/- $100
Per Visit
New here? Read how this page works
First, here is the honest picture. Nothing is open here, and nothing at all is open for adults in either Carolina. So here is how to use this page.
- Ask for a Vanderbilt or an ASRS by name. Because those are the forms clinics really use, and the Vanderbilt ones are free to download.
- Get a form from a teacher or a colleague. Also, a diagnosis needs evidence from two settings, so that form is evidence rather than paperwork.
- Ask whether a study would stop your medicine. In fact, one nearby study needs six medicine free weeks with even odds of a dummy.
- Last, tap the button. Then we keep your details on file and call you when a study opens near you.
Of course, checking never signs you up for anything. You are only seeing where you might fit.
The Nearest Studies to Charlotte
Nothing in this metro. Three run at Duke, about two hours and twenty minutes away, and all three are for children or teenagers.
The nearest three, and all are for children or teenagers
No adult study is open anywhere in either Carolina. These three run at Duke, and they differ enormously in what they ask of a family.

For Teenagers, and It Does Not Touch Medication
Duke University / Therapy study
Two non drug group programmes for teenagers, compared head to head. One teaches concrete systems, meaning planners, backpacks, tracking assignments and estimating time. The other teaches mindfulness and attention practice. Both groups get a real programme, so there is no dummy and no waiting list. Also, nothing in this study asks you to change or stop ADHD medicine.
Payment is not published.
Get on the list →More details
Why researchers are excited: for a family unwilling to interrupt medicine that is working, this is the only nearby option that leaves it completely alone. Meanwhile, both arms are real treatment.
Who this study is looking for
- Aged 13 to 17
- Also, an existing ADHD diagnosis already in the medical record
- Besides that, seeking treatment at the Duke ADHD programme
- Finally, A caregiver willing to fill in forms before and after
Probably not a fit if: the study team decides case by case. Another mental health problem that gets in the way of treating ADHD can exclude you, and the exact conditions are not named. So this is one to ask about directly rather than guess.
- Placebo group: None. Both groups get eight real sessions, and neither is a waiting list.
- How long: Eight weeks.
- Clinic visits: Eight sessions of ninety minutes each, about one a week. The record states that outright.
- Phone calls: None published. Forms are completed online before and after.
- Most invasive part: Nothing physical whatsoever. So the cost is time, travel and homework between sessions.
- Setting: Outpatient.
- Where it runs: Duke University, Durham NC 27705.
- Drive from Charlotte: Durham is about 143 miles north east, so roughly two hours and twenty minutes.
- You have to be a Duke ADHD programme patient. That means establishing care there first, which is a real step and worth knowing before you plan anything.
- Full study record: View on ClinicalTrials.gov →

For Four and Five Year Olds Only
Supernus Pharmaceuticals / Approved drug study
This tests a non stimulant approved from age six, in children aged four and five. That is the age group where doctors have the least evidence and the most hesitation. It is one capsule a day, which can be opened and sprinkled on apple sauce. Half the children get a dummy for six weeks, so it is a straight coin flip. The nearest sites are Durham, North Charleston and Summerville.
Payment is not published.
Get on the list →More details
Why researchers are excited: almost nothing has been properly tested in preschoolers, so families are left guessing. Meanwhile, this is the only ADHD drug trial recruiting anywhere in North Carolina.
Who this study is looking for
- Aged 4 years 0 months to 5 years 9 months
- Also, A symptom score at or above the study threshold, at two separate visits
- Besides that, rated at least moderately affected, again at both visits
- Finally, in a structured group activity at least two days a week, such as preschool or camp
- Also, living with the same parent or guardian for six months
Probably not a fit if: nightly melatonin rules a child out. That is a written exclusion and it quietly disqualifies a great many treated preschoolers. Also, a parent or sibling with bipolar disorder, and a body mass index above the 95th percentile or a weight below the 5th.
- Placebo group: Yes, at even odds. Half the children get a dummy capsule for the full six weeks.
- How long: Up to ten weeks in total, including up to four weeks of screening.
- Clinic visits: About 5 to 7 in person. Screening and the baseline visit are named separately in the record, and week 6 is the main measure.
- Phone calls: None published.
- Most invasive part: A heart tracing and blood work at screening. Also a long structured interview with the parent.
- Setting: Outpatient.
- Where it runs: Duke University, Durham NC 27705.
- Drive from Charlotte: Durham is about 143 miles north east, so roughly two hours and twenty minutes.
- A medicated child comes off treatment for the whole study. That is at least seven days before starting and then the full six weeks, with even odds of a dummy. So weigh it honestly.
- Full study record: View on ClinicalTrials.gov →

A Sleep and Body Clock Study, With No Treatment
Duke University with the NIMH / Measuring study
Many children with ADHD run on a late body clock, so their natural sleep signal arrives hours after bedtime. This measures that directly, with saliva samples in a dim room and a week of sleep tracking at home. Nothing is given and nothing is treated, so there is no dummy and nothing to react to. But one of the three visits is a long evening session. The site is at Durham.
Payment is not published.
Get on the list →More details
Why researchers are excited: sleep is one of the biggest untreated problems in childhood ADHD and it is rarely measured properly. Meanwhile, existing stimulant treatment is not a barrier here.
Who this study is looking for
- Aged 6 to 9
- Also, ADHD as the main diagnosis
- Besides that, medically healthy
- Finally, willing to pause melatonin for the study period
Probably not a fit if: an autism diagnosis rules a child out. So does diagnosed sleep apnoea or restless legs, which is ironic given the subject. Also, any sleep medicine other than melatonin, and plans to start a stimulant during the study.
- Placebo group: None. Nothing is given, because this only measures.
- How long: About two weeks of active participation.
- Clinic visits: Three visits, and the record says so outright. One is a night session of about five hours, often on a Friday.
- Phone calls: None published.
- Most invasive part: No needles and no drug, but eleven saliva samples across a five hour evening. Also three sensors worn every night for a week.
- Setting: Outpatient.
- Where it runs: Duke University Medical Center, Durham NC 27705.
- Drive from Charlotte: Durham is about 143 miles north east, so roughly two hours and twenty minutes.
- The night session is the whole decision. Five hours ending near midnight, two hours from Charlotte, almost certainly means an overnight stay.
- Full study record: View on ClinicalTrials.gov →
Not sure which one fits you?
First, answer a few quick health questions. Then we keep them on file. Finally, we call you when a study opens near Charlotte. No account, no paperwork.
See if I may fit one of these studies →What Is Actually Happening in ADHD Care
The research is almost entirely in children, while the fastest growing group being diagnosed is adults.
Adult ADHD Is Real and Routinely Missed
It does not stop at eighteen, and in women it far more often looks like disorganisation, forgetfulness and constant overwhelm rather than visible restlessness. So a lot of women are diagnosed in their thirties or forties, often after their own child is assessed. Meanwhile, being called spacey or a daydreamer as a girl is a reason to ask, not a reason to dismiss.
A Proper Adult Diagnosis Looks at Childhood
This is a condition that starts early, so an assessment has to find signs before about age twelve. Bring old school reports, and ask a parent or older sibling what you were like at eight. So that step is what separates ADHD from anxiety, depression, poor sleep and thyroid problems. Also, a clinic that diagnoses you in fifteen minutes without asking about childhood has skipped it.
Stimulants and Non Stimulants Are Different Tools
Stimulants often work within an hour of the right dose and wear off the same day. Non stimulants take two to six weeks to show their full effect and work around the clock. So judging a non stimulant after five days is not a fair trial of it. In fact, the only ADHD drug study recruiting anywhere in North Carolina is testing a non stimulant.
Non Stimulants Are Not a Consolation Prize
They are often the better first choice where there is a substance use history. The same holds where stimulants caused anxiety or sleep problems. It holds again where a family prefers a drug that is not controlled. So ask what a non stimulant trial would look like and how long before you would know. Meanwhile, that question is asked far less often than it should be.
The Stimulant Shortage Is Structural
These drugs sit under yearly production quotas. Also, you cannot usually move a prescription between pharmacies the way you can with ordinary ones. So call ahead to check stock before the prescription is sent, because an unfilled one can strand you. Also, ask whether a different formulation is in stock, or whether a non stimulant could bridge the gap. In general, tell the prescriber’s office rather than simply waiting.
Ask for the Rating Scales by Name
For adults the names are ASRS, AISRS and ACDS. For children they are the Vanderbilt scales, the ADHD Rating Scale and the Conners. So saying can we do a Vanderbilt with a teacher form moves an appointment forward faster than anything else. In fact, the Vanderbilt forms are free and downloadable.
A Diagnosis Needs Two Settings
ADHD is defined by difficulty in more than one environment, so a teacher form is evidence rather than paperwork. For an adult that means work or study as well as home. So if no one has asked for outside information, the assessment is incomplete. Meanwhile, one study near Charleston exists precisely because those teacher forms so often never come back.
Ask Whether a Study Stops Your Medication
This is where families are most often blindsided. The preschool drug study asks you to stop ADHD medicine at least a week before and to stay off it for the full six weeks, with even odds of a dummy. By contrast the teenage skills study asks for no medicine change at all. So ask it in those exact words on the first call.
Ordinary Things Disqualify People
Nightly melatonin excludes a child from the preschool study, and that is extremely common. A parent or sibling with bipolar disorder excludes them too. A single course of an antipsychotic years ago permanently excludes a child from the study near Charleston. So read the boring criteria and volunteer the full medicine history, supplements included.
Nothing Today Is Not Nothing Ever
Nothing at all is recruiting in either metro right now, and no adult ADHD study is recruiting anywhere in either Carolina. That is the truth and it saves wasted phone calls. But it changes fast, and at least one adult study is due to begin enrolling with no sites announced yet. Meanwhile, ask your own clinician whether their practice has been approached as a site.
ADHD Help Near You
Ask for a Vanderbilt or an ASRS by name, and get a form from a teacher or a colleague. Also, ask whether a study would require stopping medicine, before anything else. Last, if you are an adult, ask about childhood evidence, since that is the step most often skipped. Meanwhile, join the list and we will call you when something opens near you.
Research Sites Near Charlotte
Nothing runs in this metro for ADHD today, while the nearest sites sit at Duke in Durham. But sites add new studies all the time, so it is worth being on the list.

Atrium Health
Multiple Charlotte locations / 161+ active studies
Crohn’s, Heart Failure, COPD, Dementia, Type 2 Diabetes, Hypertension
Charlotte’s biggest health system. It is tied to Wake Forest University School of Medicine. Also, it runs far more trials than anyone else nearby.
Visit Website →
American Health Research Network
Ballantyne, NC 28277 / 25 to 30+ active studies
Asthma, COPD, Chronic Cough, Type 2 Diabetes
Led by Dr. Selwyn Spangenthal. It is the biggest private lung research group in Charlotte. Specifically, it has 4 offices: Charlotte, Rock Hill, Lake Norman, and Charleston.
Visit Website →
Monroe Biomedical Research
Monroe, NC / 17+ active studies
Asthma, COPD, Hypertension, Obesity, Ulcerative Colitis
Notably, one of the 5 busiest research sites in the country. Its 6,300 sq ft space can host overnight stays. It is also an SCRS Global Impact Partner.
Visit Website →
Clinical Research of Gastonia
Gastonia, NC / 11+ active studies
Asthma, COPD, Chronic Cough, Idiopathic Hypersomnia
Led by Dr. Anup Banerjee. Its 3,500 sq ft space sits next to CaroMont Regional Medical Center. Also, it has been running for over 10 years.
Visit Website →
OnSite Clinical Solutions
Ballantyne, NC 28277 / 10+ active studies
Ulcerative Colitis, Crohn’s, COPD, Heart Failure, Atopic Dermatitis
It works with Charlotte doctors in heart, gut, skin, nerve, and joint care. Besides, it runs studies from Phase I through Phase IV.
Visit Website →
Flourish Research
Matthews, NC 28105 / 4+ active studies
Alzheimer’s Disease, Early Alzheimer’s, Alzheimer’s-Related Psychosis
Led by Dr. M. Reza Bolouri. He has 20+ years in Alzheimer’s research. The site is an Alzheimer’s Center of Excellence. In fact, its network has finished 5,500+ trials.
Visit Website →
New Hope Clinical Research
SouthPark, NC 28211 / 4+ active studies
Major Depression, Schizophrenia, Bipolar Disorder
Led by Dr. Kurian Abraham. It runs Phase I through IV studies and has 30 beds for overnight stays. Its last FDA audit came back clean. Also, it has finished 200+ brain studies.
Visit Website →
Queen City Clinical Research
SouthPark, NC 28211 / 2+ active studies
Chronic Pain, Chronic Migraine, Osteoarthritis
Led by Dr. Leonardo Kapural, a former Cleveland Clinic professor. Notably, he has written 200+ journal articles. On top of that, many call this the biggest pain research site in the country.
Visit Website →
Novant Health
Multiple Charlotte locations / Several active studies
Cardiovascular Disease, Obesity, Hypertension
One of the biggest health systems in the Carolinas. Its Heart and Vascular Institute runs heart studies and sees a lot of patients.
Visit Website →
DLVSC
4 Charlotte-area offices / 1+ active studies
Eczema, Psoriasis, Rosacea
Led by Dr. Gilly Munavalli. This award-winning skin practice owns 50+ FDA-approved lasers and devices. Also, it has its own research team.
Visit Website →
DelRicht Research
South Charlotte, NC 28210 / 1+ active studies
Bipolar Disorder, Bipolar Depression
Part of a national network of mental health research sites. Currently, it runs the azetukalner bipolar depression trial in Charlotte. Previously, it ran other mental health studies.
Visit Website →
TMS of the Carolinas
South Charlotte, NC 28210 / 1+ active studies
Major Depression, Treatment-Resistant Depression
A specialty site for brain stimulation care. It runs the fast TMS study that packs 6 weeks into 2.
Visit Website →What to Expect in an ADHD Study
New to studies? Here is how one works, step by step.
01
Prescreening
First comes a short phone call or online form. Also, it takes about 10 to 15 minutes. The staff check whether you might fit. Then they tell you what is open.
02
Screening Visit
Next the clinic runs the tests that decide it, which usually means blood work. Also, they go through the consent form line by line, and you can bring somebody with you.
03
Treatment Period
Then the study begins. So you take the study drug or the placebo on the agreed schedule. Meanwhile, your own doctor keeps managing everything else.
04
Follow-Up
Finally, there is a check in period at the end. Also, your own doctor gets the results, and you can stop at any point without affecting your care.
ADHD Trial FAQs
Real answers about adhd studies near Charlotte NC.
Is there a study for this near Charlotte?
No, and we will not pretend otherwise. Every one of the twenty two towns in this metro was swept on its own. There is also no adult study of any kind recruiting anywhere in North or South Carolina, which is worth saying outright. But three run at Duke about two hours and twenty minutes away, and all three are for children or teenagers. Also, one of those asks for no medicine change at all.
Is adult ADHD real?
Yes, and it is missed constantly, especially in women. In girls it far more often looks like disorganisation, forgetfulness and constant overwhelm rather than restlessness. So many women are diagnosed in their thirties or forties, often after their own child is assessed. Meanwhile, being called a daydreamer as a girl is a reason to ask, not a reason to dismiss.
Why do they ask about my childhood?
Because this starts early, so an assessment has to find signs before about age twelve. Bring old school reports, and ask a parent or older sibling what you were like at eight. So that step is what separates it from anxiety, low mood, poor sleep and thyroid problems. Also, a clinic that diagnoses you in fifteen minutes without asking has skipped it.
What is the difference between the two kinds of drug?
Stimulants often work within an hour of the right dose and wear off the same day. The other kind takes two to six weeks to show its full effect and works around the clock. So judging the second kind after five days is not a fair trial of it. In fact, the only drug study recruiting in North Carolina is testing that second kind.
Why can I not get my prescription filled?
These drugs sit under yearly production limits, and prescriptions cannot be moved between pharmacies easily. So call ahead to check stock before the prescription is sent. Also, ask whether a different form is in stock, or whether a non stimulant could bridge the gap. Meanwhile, tell the prescriber’s office rather than simply waiting.
What are the rating scales called?
For adults, the ASRS, the AISRS and the ACDS. For children, the Vanderbilt scales and the ADHD Rating Scale. So saying can we do a Vanderbilt with a teacher form moves an appointment along faster than anything else. Also, the Vanderbilt forms are free and you can download them. Also, the teacher form is evidence rather than paperwork.
Would a study stop my medicine?
Sometimes, and this is where families get blindsided. The preschool drug study asks you to stop at least a week before and to stay off for the whole six weeks. By contrast the teenage skills study asks for no medicine change at all. So ask it in those exact words on the first call.
What ordinary things disqualify people?
Nightly melatonin rules a child out of the preschool study, and that is extremely common. So does a parent or sibling with bipolar disorder, or a weight outside a set range. One study near Charleston permanently excludes a child who ever had a course of an antipsychotic. So volunteer the full medicine history including supplements.
Does it cost anything to check?
No. There is no cost, and no insurance is needed. Tether is a nonprofit list, so we do not run studies and we are not paid to send you anywhere. Also, checking never enrolls anyone in anything. You would always call the clinic yourself.
Where can I get help near Charlotte?
Atrium Health and Novant Health both run behavioural health services across the metro. Also, ask for a Vanderbilt or an ASRS by name, and get a form from a teacher or a colleague. In general, an adult assessment should ask about your childhood, and one that does not has skipped a step. Meanwhile, ask your own clinic whether they have been approached about hosting a study.
Ready to Explore a Study?
Check your eligibility, or just reach out to our Charlotte team. No pressure. Also, no sales pitch.
← Back to All Clinical TrialsSources
- A non stimulant tested in four and five year olds, at Durham and Charleston, ClinicalTrials.gov NCT04781140
- Two real skills programmes for teenagers, at Duke, ClinicalTrials.gov NCT07089745
- CIRCA, a body clock study in children aged 6 to 9, at Duke, ClinicalTrials.gov NCT06971640
- RAMP, text based monitoring with no clinic visits, at Charleston, ClinicalTrials.gov NCT06743425
- A study listing a Columbia SC site whose own row is closed, ClinicalTrials.gov NCT04278404
Study details and per-site recruiting status verified against ClinicalTrials.gov on August 17, 2026, with all 22 Charlotte metro towns and all 14 Columbia metro towns swept individually. Two findings are worth stating outright. Nothing is open in either metro. Also, no adult study of any kind is open in either state. Every open option is for children. The most misleading record here reads as recruiting and lists a real University of South Carolina site in Columbia. But that row’s own status is completed. So checking the state field and stopping there would give the wrong answer. A state level search returned one study in North Carolina and two in South Carolina. Both answers were wrong. City sweeps found roughly three times as many. Study openings and criteria change. The research clinic confirms it all before you enroll.