CHARLOTTE, NC

Neuropathy Clinical Trials

Three neuropathy studies are enrolling near Charlotte NC, and they are three unrelated conditions. None of them serves nerve damage from diabetes, which is the commonest cause, and we would rather say so. Compensation is provided for eligible participants.

3

Open Near Charlotte

3

Different Conditions

+/- $100

Per Visit

New here? Read how this page works

First, here is the honest picture. Three studies are open, and they treat three different diseases. So here is how to use this page.

  1. Find out what is causing yours. Because neuropathy is a word for several different diseases, and the cause decides which studies exist for you.
  2. Ask for four ordinary blood tests. Notably, vitamin B12, thyroid, kidney function and a blood count explain a real share of unexplained cases.
  3. If chemotherapy is coming, raise prevention now. In fact, one study here has to start within three days of your first dose.
  4. Finally, tap the button. Then we check you against every study we track and tell you which ones fit.

Of course, checking never signs you up for anything. You are only seeing where you might fit.

Studies Open Near Charlotte Right Now

Three of them, and they share only a word. So read what each one is actually for before you call anybody.

Three studies, and three completely different conditions

They share one word and nothing else. One prevents nerve damage from chemotherapy, one treats an immune attack on the nerves, and one compares two operations for a trapped nerve.

Stopping Nerve Damage Before It Starts

SWOG Cancer Research Network / Late stage device

This is prevention rather than treatment, and the timing is everything. It is for people about to start certain chemotherapy drugs that often damage the nerves. Wraps cool or squeeze your arms and legs during each infusion, so less drug reaches the hands and feet. Every group gets a real working device, because the three arms differ in what the device does. So there is no dummy and no fake wrap anywhere in it.

Late stage study, 777 people No dummy

Payment is not published.

Check eligibility →
More details

Why researchers are excited: numb, burning hands and feet after chemotherapy can last for years, and nothing reliably reverses it. Meanwhile, the only real chance to act is before the first dose.

Who this study is looking for

  • A solid tumour, rather than a blood cancer
  • Also, starting one of the named chemotherapy plans within three days of joining
  • Besides that, no nerve damage already, from any cause
  • Finally, able to fill in the forms in English or Spanish

Probably not a fit if: any nerve damage you already have rules you out. So mild tingling from diabetes often ends it at screening. Also, any earlier chemotherapy known to harm nerves, and fingers that go white in the cold.

  • Placebo group: None. All three groups wear a real device, and they differ only in cooling and pressure.
  • How long: The device is used at every infusion. Nerve checks run to 52 weeks.
  • Clinic visits: About 5 study visits, at the start and at weeks 6, 12, 24 and 52. However, the device is used at every chemotherapy session, so each of those appointments runs about an hour longer.
  • Phone calls: None published.
  • Most invasive part: Nothing added beyond optional blood samples. So the common complaint is simply that the cooling is cold and hard to sit through.
  • Setting: Outpatient.
  • Where it runs: CaroMont Regional Medical Center, Gastonia NC 28054.
  • Drive from Charlotte: Gastonia is about 22 miles west, so roughly half an hour.
  • Raise this at the treatment planning visit. The three day window is brutal, and anyone already partway through chemotherapy is too late. So ask before your first dose.
  • Full study record: View on ClinicalTrials.gov →

For the Autoimmune Kind, Called CIDP

Janssen / Late stage infusion

CIDP is the kind where your own immune system strips the coating off your nerves. It causes weakness and numbness that build up over weeks or months, in arms and legs. This drug is a drip that lowers the harmful antibodies in your blood. However, the shape of this study is unusual and you need to understand it before calling. The site is inside Charlotte.

Late stage study, 201 people Recruiting

Payment is not published.

Check eligibility →
More details

Why researchers are excited: the current treatments are steroids and antibody infusions, and neither suits everybody. Meanwhile, a drug that removes the harmful antibodies directly is a different approach.

Who this study is looking for

  • CIDP diagnosed by the current criteria, and confirmed again by an outside panel
  • Also, A disability score in the study’s range, so ask for your INCAT number
  • Besides that, active disease rather than settled disease
  • Finally, aged 18 or over, with no upper limit

Probably not a fit if: nerve damage most likely caused by diabetes rules you out. Also, the purely sensory form of CIDP, and several named look alike conditions. Notably, uncontrolled illness elsewhere in the body also excludes.

  • Placebo group: Yes, but only in the second stage. Everybody gets the real drug for the first twelve weeks.
  • How long: A run in, then twelve weeks on the drug, then up to a further year.
  • Clinic visits: Roughly 25 to 40 in person, because the drug is a drip given at the site across more than a year. But treat that as an estimate, since the interval is not published.
  • Phone calls: None published.
  • Most invasive part: Drips into a vein, and coming off your current treatment first. So people on regular antibody infusions have to stop them to take part.
  • Setting: Outpatient.
  • Where it runs: The Neurological Institute, Charlotte NC 28204.
  • Drive from Charlotte: The site is in Charlotte, off East Morehead Street.
  • Ask two questions before anything else. What happens if you get worse during the run in, and what the odds are of being moved to a dummy in the second stage.
  • Full study record: View on ClinicalTrials.gov →

Two Real Operations for a Trapped Elbow Nerve

University of Michigan with OrthoCarolina / Surgery study

This is for a nerve squeezed at the inside of the elbow, which numbs the ring and little fingers. Two standard operations exist and surgeons disagree about which is better. So this study settles it by assigning one of the two at random. Both are real, and there is no fake surgery and no group left without an operation. The site is inside Charlotte.

Surgery study, 378 people No dummy

Payment is not published.

Check eligibility →
More details

Why researchers are excited: thousands of these operations are done every year with no clear answer on which works better. Meanwhile, both arms here are ordinary care rather than anything experimental.

Who this study is looking for

  • Numbness or weakness from the ulnar nerve at the elbow, on its own
  • Also, nerve tests confirming it, using set numbers you can ask for
  • Besides that, having already tried splinting or other non surgical care
  • Finally, able to complete the forms in English

Probably not a fit if: carpal tunnel in the same arm rules you out. That is very common, and it is the usual reason people are turned away here. Also, a previous operation on the same nerve, and a nerve that slips out of place.

  • Placebo group: None. Everybody has a real operation, because the two groups are two real techniques.
  • How long: A year, with checks at two weeks, six weeks, three months and twelve months.
  • Clinic visits: About 6 in person, which are enrolment with the nerve test, the surgery, then two weeks, six weeks, three months and twelve months.
  • Phone calls: None published.
  • Most invasive part: An operation under anaesthetic, and that is the treatment. Also, nerve tests beforehand, plus grip and sensation testing at each visit.
  • Setting: Outpatient.
  • Where it runs: OrthoCarolina Research Institute, Charlotte NC 28207.
  • Drive from Charlotte: The site is in Charlotte, at OrthoCarolina.
  • You do not choose your operation. So be sure you are comfortable with either before you consent. Ask the surgeon to explain both in plain terms.
  • Full study record: View on ClinicalTrials.gov →

Not sure which one fits you?

First, answer a few quick health questions. Then we keep them on file. Finally, we tell you which studies near Charlotte you may fit. No account, no paperwork.

See if I may fit one of these studies →
✓ Takes just a few minutes✓ No cost, no obligation✓ You are never enrolled by checking

Why Nerve Damage Research Matters Here in Charlotte

Feet that are numb and burning at the same time

Numbness that somehow still hurts, pins and needles that arrive at night, and a floor you cannot quite feel. Meanwhile, the balance goes before anybody mentions it, and that is what leads to falls. So stairs, dark rooms and uneven ground all become decisions. In fact, many people are told it is simply age long before anyone looks for a cause.

What is actually being studied here

Rock Hill, Concord, Gastonia, Huntersville, Matthews, Mooresville. Three studies are open in this metro, and the striking thing is how little they have in common. One prevents nerve damage before chemotherapy starts. One treats an immune attack on the nerve coating. One compares two operations for a nerve trapped at the elbow. However, none of the three serves the numb burning feet that diabetes causes, which is the commonest case here.

So why is the commonest cause the least covered?

  • Diabetic damage is studied for its pain. Most trials aim at the pain rather than the nerve. So they sit on our nerve pain page instead.
  • Reversing nerve damage is very hard. Nothing yet reliably repairs it. Meanwhile, prevention and pain relief are the achievable targets.
  • The immune form is rare and fundable. Small numbers, but a clear target. However, that means one specialist practice carries it.
  • Trapped nerves belong to surgeons. That study exists because a large orthopaedic group runs research. So it is here for that reason.
  • A fourth study is listed but not open. Another immune form study lists a Charlotte site that has not opened. In fact, we will not count it until it does.

Research is a care option, not a last resort

There is a saying in medicine that research is a care option rather than a last resort. Generally, that is the honest way to think about a study. You are not giving up your own doctor. Instead, you are adding a second set of eyes. Notably, two of the three studies here have no dummy group at all, because every participant receives a real device or a real operation.

What being on the list actually gets you

This is a directory, not a clinic. So being on the list is simple and it costs nothing.

What you actually get

  • A call from us the day a new study opens near you
  • The clinic name and number, so you call them yourself
  • A check against every other study on our list, not just this one
  • No cost, and no insurance needed
  • Roughly $100 a visit for your time, once you are in a study
  • You are never enrolled by checking

So add it up. Three studies here, covering three unrelated conditions, and none for the diabetic kind. Meanwhile, the four ordinary blood tests are still worth asking for, since some causes are treatable and get missed. So the useful thing to do today is find out what is causing yours, because that decides everything else.

What Is Actually Happening in Nerve Damage Research

The word covers several different diseases, and which one you have decides everything that follows.

One Word, Several Different Diseases

Neuropathy just means nerve damage, and it says nothing about the cause. So the numb feet of diabetes, an immune attack on the nerve coating and a trapped nerve at the elbow all carry the same label. Meanwhile, they go to completely different studies. Notably, naming your cause is the single most useful thing you can do before calling anyone.

Most Cases Start at the Feet

The longest nerves reach the toes, so they fail first. That is why it usually begins as numbness or burning in both feet and creeps upwards. So doctors call the pattern stocking and glove, because the hands follow later. In fact, that shape is a clue to the cause on its own.

Diabetes Is the Commonest Cause by Far

Roughly half of people with long standing diabetes develop some nerve damage. So blood sugar control is the treatment as well as the prevention. Meanwhile, the studies open near here do not serve that group, and we would rather say so. However, our nerve pain page covers the studies aimed at the pain it causes.

Ask Whether Anyone Has Looked for a Cause

A real share of cases labelled unexplained turn out to have a treatable cause behind them. Vitamin B12, thyroid, kidney function and a full blood count are the usual first tests. So ask for those by name, because they are ordinary and your own doctor can order them. Also, alcohol and some medicines are common causes people are never asked about.

The Nerve Test Is Not as Bad as It Sounds

A nerve conduction study uses surface pads and small electrical pulses to time your nerves. So it is uncomfortable rather than painful, and it takes under an hour. Meanwhile, its numbers are what several studies gate on. Notably, the elbow study on this page has exact thresholds you can ask about.

Some Nerve Damage Is Preventable

Certain chemotherapy drugs damage nerves in a large share of people who receive them. So one study here tries to stop that happening at all, using cooling and pressure during the infusion. However, it has to start before your first dose, which is a very tight window. In fact, that timing is the whole reason to raise it early.

The Immune Kind Comes On Differently

CIDP is an immune attack on the coating around the nerves, and weakness leads rather than numbness. It builds over weeks or months, and it often affects both sides equally. So it is treatable in a way most nerve damage is not. Meanwhile, being told your case is simply diabetes when it is this is a real and costly mistake.

A Trapped Nerve Is Its Own Category

When one nerve is squeezed at one spot, that is a different problem entirely. The ulnar nerve at the elbow is the classic case, numbing the ring and little fingers. So an operation can fix it, which is not true of most nerve damage. Notably, having carpal tunnel as well rules you out of the study here.

Damage and the Pain It Causes Are Studied Apart

Some studies aim at the nerve damage itself, and others aim only at the pain. So it is worth knowing which you are being offered. Meanwhile, the three studies open near Charlotte are all aimed at the damage. Generally, the pain studies sit on a separate page and have separate rules.

Where Things Actually Stand Locally

Three studies are open around Charlotte, and they are three unrelated conditions. The Midlands has none, and that was checked town by town rather than assumed. So the nearest options for a Columbia patient sit at Union, Greenville and Charleston. However, a second study for the immune kind lists a Charlotte site that has not opened yet.

Nerve Damage Help Near You

Ask what is causing yours, because the answer decides which studies exist for you. Also, ask for the four ordinary blood tests, since some causes are treatable and get missed. Finally, if chemotherapy is coming, raise prevention before your first dose rather than after. Meanwhile, join the list and we will call you when something opens near you.

Research Sites Near Charlotte

OrthoCarolina, The Neurological Institute and CaroMont at Gastonia all run studies in this area. But sites add new studies all the time, so it is worth knowing what is near you.

Atrium Health

Multiple Charlotte locations / 161+ active studies

Crohn’s, Heart Failure, COPD, Dementia, Type 2 Diabetes, Hypertension

Charlotte’s biggest health system. It is tied to Wake Forest University School of Medicine. Also, it runs far more trials than anyone else nearby.

Visit Website →

American Health Research Network

Ballantyne, NC 28277 / 25 to 30+ active studies

Asthma, COPD, Chronic Cough, Type 2 Diabetes

Led by Dr. Selwyn Spangenthal. It is the biggest private lung research group in Charlotte. Specifically, it has 4 offices: Charlotte, Rock Hill, Lake Norman, and Charleston.

Visit Website →

Monroe Biomedical Research

Monroe, NC / 17+ active studies

Asthma, COPD, Hypertension, Obesity, Ulcerative Colitis

Notably, one of the 5 busiest research sites in the country. Its 6,300 sq ft space can host overnight stays. It is also an SCRS Global Impact Partner.

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Clinical Research of Gastonia

Gastonia, NC / 11+ active studies

Asthma, COPD, Chronic Cough, Idiopathic Hypersomnia

Led by Dr. Anup Banerjee. Its 3,500 sq ft space sits next to CaroMont Regional Medical Center. Also, it has been running for over 10 years.

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OnSite Clinical Solutions

Ballantyne, NC 28277 / 10+ active studies

Ulcerative Colitis, Crohn’s, COPD, Heart Failure, Atopic Dermatitis

It works with Charlotte doctors in heart, gut, skin, nerve, and joint care. Besides, it runs studies from Phase I through Phase IV.

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Flourish Research

Matthews, NC 28105 / 4+ active studies

Alzheimer’s Disease, Early Alzheimer’s, Alzheimer’s-Related Psychosis

Led by Dr. M. Reza Bolouri. He has 20+ years in Alzheimer’s research. The site is an Alzheimer’s Center of Excellence. In fact, its network has finished 5,500+ trials.

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New Hope Clinical Research

SouthPark, NC 28211 / 4+ active studies

Major Depression, Schizophrenia, Bipolar Disorder

Led by Dr. Kurian Abraham. It runs Phase I through IV studies and has 30 beds for overnight stays. Its last FDA audit came back clean. Also, it has finished 200+ brain studies.

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Queen City Clinical Research

SouthPark, NC 28211 / 2+ active studies

Chronic Pain, Chronic Migraine, Osteoarthritis

Led by Dr. Leonardo Kapural, a former Cleveland Clinic professor. Notably, he has written 200+ journal articles. On top of that, many call this the biggest pain research site in the country.

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Novant Health

Multiple Charlotte locations / Several active studies

Cardiovascular Disease, Obesity, Hypertension

One of the biggest health systems in the Carolinas. Its Heart and Vascular Institute runs heart studies and sees a lot of patients.

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DLVSC

4 Charlotte-area offices / 1+ active studies

Eczema, Psoriasis, Rosacea

Led by Dr. Gilly Munavalli. This award-winning skin practice owns 50+ FDA-approved lasers and devices. Also, it has its own research team.

Visit Website →

DelRicht Research

South Charlotte, NC 28210 / 1+ active studies

Bipolar Disorder, Bipolar Depression

Part of a national network of mental health research sites. Currently, it runs the azetukalner bipolar depression trial in Charlotte. Previously, it ran other mental health studies.

Visit Website →

TMS of the Carolinas

South Charlotte, NC 28210 / 1+ active studies

Major Depression, Treatment-Resistant Depression

A specialty site for brain stimulation care. It runs the fast TMS study that packs 6 weeks into 2.

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What to Expect in a Nerve Study

New to studies? Here is how one works, step by step.

01

Prescreening

First comes a short phone call or online form. Also, it takes about 10 to 15 minutes. The staff check whether you might fit. Then they tell you what is open.

02

Screening Visit

Next the clinic runs the tests that decide it, which usually means blood work. Also, they go through the consent form line by line, and you can bring somebody with you.

03

Treatment Period

Then the study begins. So you take the study drug or the placebo on the agreed schedule. Meanwhile, your own doctor keeps managing everything else.

04

Follow-Up

Finally, there is a check in period at the end. Also, your own doctor gets the results, and you can stop at any point without affecting your care.

Neuropathy Trial FAQs

Real answers about nerve damage studies near Charlotte NC.

Is there a study for this near Charlotte?

Yes, three, and they are three different conditions. One prevents nerve damage in people about to start certain chemotherapy. One treats an immune attack on the nerve coating, called CIDP. One compares two operations for a nerve trapped at the elbow. However, none of them is for nerve damage caused by diabetes.

Does neuropathy mean one thing?

No, and that is the most useful thing to know here. It just means nerve damage, and it says nothing about the cause. So the numb feet of diabetes, an immune attack on the nerve coating and a trapped nerve at the elbow all carry the same label. Meanwhile, they go to completely different studies.

Why does it start in my feet?

Because the longest nerves reach the toes, so they fail first. That is why it usually begins as numbness or burning in both feet and creeps upwards over time. So doctors call the pattern stocking and glove, since the hands follow later. In fact, that shape is a clue to the cause on its own.

Is there anything for nerve damage from diabetes?

Not on this page, and we would rather say that plainly. The studies open near here are for chemotherapy prevention, for an immune form, and for a trapped nerve at the elbow. So none of them serves the commonest cause. However, our nerve pain page covers the studies aimed at the pain that diabetes causes, and there is one near Charlotte.

Which blood tests should I ask for?

Four of them, and your own doctor can order all four. Vitamin B12, thyroid, kidney function and a full blood count. So those cover a real share of the causes that get missed. Also, alcohol and certain medicines are common causes that people are simply never asked about.

What is a nerve conduction study like?

Surface pads and small electrical pulses time how fast your nerves carry signals. So it is uncomfortable rather than painful, and it usually takes under an hour. Meanwhile, its numbers are what several studies gate on. Notably, the elbow study near Charlotte has exact thresholds you can ask about by name.

Can nerve damage from chemotherapy be prevented?

That is exactly what one nearby study is testing, using cooling and pressure wraps during each infusion. Every group wears a real working device, so there is no dummy in it. However, it has to begin within three days of your first chemotherapy dose. So raise it at the treatment planning visit rather than afterwards, because afterwards is too late.

Does it cost anything to check?

No. There is no cost, and no insurance is needed. Tether is a nonprofit list, so we do not run studies and we are not paid to send you anywhere. Also, checking never enrolls anyone in anything. You would always call the clinic yourself.

Where can I get help near Charlotte?

Atrium Health and Novant Health both run neurology services across the metro, and The Neurological Institute is a specialist practice here. Also, ask what is causing your nerve damage, because the answer decides which studies exist for you. Generally, your own doctor can order the first blood tests. Meanwhile, ask about a nerve conduction study if nobody has arranged one.

Ready to Explore a Study?

Check your eligibility, or just reach out to our Charlotte team. No pressure. Also, no sales pitch.

← Back to All Clinical Trials

Sources

Study details and per-site recruiting status verified against ClinicalTrials.gov on August 17, 2026. The three studies near Charlotte are three unrelated conditions that share one word, and none of them serves nerve damage caused by diabetes, which is the commonest cause by a wide margin. A second study for the immune form lists a Charlotte site, but that row has not opened yet, so it is named as a watch item rather than published as an option. The Columbia zero was checked town by town, and separately for the small fibre, inherited and chemotherapy related forms. Six searches on the word Columbia returned sites in New York, Missouri and Maryland instead. Study availability and criteria change; the research clinic confirms everything before you enroll.

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