CHARLOTTE, NC

Nerve Pain Clinical Trials

One study for diabetic nerve pain is enrolling about twenty five miles from Charlotte NC, at Monroe. A second study inside the city is for a different condition entirely, and we say which on its card. Compensation is provided for eligible participants.

1

For Diabetic Nerve Pain

25

Miles to That Site

+/- $100

Per Visit

New here? Read how this page works

First, here is the honest picture. One study fits the common kind, and the second is a different condition. So here is how to use this page.

  1. Get your latest HbA1c. Because nine or under is the gate, and above nine closes the door until it comes down.
  2. Start scoring your pain daily now. Notably, the first seven days are a real gate, and missing more than three of them excludes you.
  3. Ask what happens to your current nerve pain medicine. In fact, that is not published, and stopping one is a decision for your own doctor.
  4. Finally, tap the button. Then we check you against every study we track and tell you which ones fit.

Of course, checking never signs you up for anything. You are only seeing where you might fit.

Studies Open Near Charlotte Right Now

Two, though only one is for the burning feet of diabetes. Notably, a plain search of this metro returns neither.

For the burning feet of diabetes

One study is open for this, and the site is about half an hour from uptown. Notably, a search on nerve pain in Charlotte returns nothing at all, which is simply wrong.

A Tablet Aimed Only at Pain Nerves

Vertex / Late stage tablet

This is for the burning, stabbing pain of diabetic nerve damage in both feet and lower legs. The tablet blocks a channel that sits almost only on pain sensing nerves outside the brain. So the aim is relief without the fog or habit risk of the usual drugs. Half the group gets a dummy tablet, because there is no active comparison arm in this one. The site is at Monroe.

Late stage study, 734 people Recruiting

Payment is not published.

Check eligibility →
More details

Why researchers are excited: the standard drugs for this were borrowed from epilepsy and depression, and many people cannot tolerate them. Meanwhile, this class is genuinely new.

Who this study is looking for

  • Type 1 or type 2 diabetes
  • Also, an HbA1c of 9 or under
  • Besides that, pain in both feet or lower legs from nerve damage, for a year or more
  • Finally, A weekly average pain score between 4 and 9 out of 10
  • Also, aged 18 to 80, with a body mass index under 40

Probably not a fit if: missing more than three diary days in the first week rules you out. So the diary is a gate, not a formality. Also, an HbA1c above 9, and pain under 4 or above 9 out of 10.

  • Placebo group: Yes. It is the tablet against a dummy, with no active drug in the other arm.
  • How long: A seven day diary period first, then the main measure at week 12.
  • Clinic visits: Roughly 6 to 9 in person across the twelve weeks. But treat that as an estimate, since only week 12 is published.
  • Phone calls: None published.
  • Most invasive part: Blood tests and a daily pain diary. So there is no procedure, and the diary is the demanding part.
  • Setting: Outpatient.
  • Where it runs: Monroe Biomedical Research, Monroe NC 28112.
  • Drive from Charlotte: Monroe is about 25 miles south east, so roughly 35 minutes on US-74.
  • Ask about your current nerve pain medicine first. Whether gabapentin can continue is not published, so ask your own doctor.
  • Full study record: View on ClinicalTrials.gov →

And one for a different condition entirely

This one is for CRPS, where a limb turns hot, red and swollen after an injury. It is listed because people searching nerve pain will find it, not because it is the same thing.

For a Limb That Turned Hot and Swollen After Injury

Ambros Therapeutics / Late stage drip

Sometimes after an injury one limb becomes intensely painful, red, hot and swollen. The pain is far out of proportion to the injury, and it is called CRPS. This tests four drips over ten days, against a dummy, in the early stage of it. However, the window is tight, because you have to be within six months of it starting. The site is inside Charlotte.

Late stage study, 270 people Recruiting

Payment is not published.

Check eligibility →
More details

Why researchers are excited: almost nothing is approved for this, and the early months are when the odds are best. Meanwhile, most people reach a study listing years too late to qualify.

Who this study is looking for

  • CRPS in one limb, diagnosed on the standard clinical criteria
  • Also, within six months of it starting
  • Besides that, the hot kind, with swelling plus redness or a limb a degree warmer than the other
  • Finally, A bone scan showing increased uptake in that limb

Probably not a fit if: a known nerve injury rules you out. So this takes the form without nerve damage, which is the opposite of what people assume. Also, the cold kind, and having had it longer than six months.

  • Placebo group: Yes. It is drips against dummy drips, and nobody involved knows which.
  • How long: About eighteen weeks, with the main measure at week 12.
  • Clinic visits: About 8 to 10 in person. Four of those are the drips on days 1, 4, 7 and 10, then checks at weeks 3, 6, 9 and 12.
  • Phone calls: None published.
  • Most invasive part: A bone scan at screening, plus four drips inside ten days. So the scan means an injected tracer and imaging over hours.
  • Setting: Outpatient.
  • Where it runs: Ambros clinical trial site, Charlotte NC 28211.
  • Drive from Charlotte: The site is in Charlotte, though the clinic name is not published.
  • Sort your dental and vitamin D questions early. An unhealed tooth extraction site excludes you, and so does low vitamin D or calcium. Notably, those last two are fixable, so ask about re-checking.
  • Full study record: View on ClinicalTrials.gov →

Not sure which one fits you?

First, answer a few quick health questions. Then we keep them on file. Finally, we tell you which studies near Charlotte you may fit. No account, no paperwork.

See if I may fit one of these studies →
✓ Takes just a few minutes✓ No cost, no obligation✓ You are never enrolled by checking

Why Nerve Pain Research Matters Here in Charlotte

Burning feet that get worse the moment you lie down

Burning, stabbing, and electric shocks in both feet, arriving hardest at night when nothing distracts you. Meanwhile, the sleep goes first, and everything else follows it downhill. So people describe socks that hurt and a floor they cannot quite feel, both at once. In fact, ordinary painkillers doing nothing is one of the most reliable clues that this is nerve pain.

What is actually being studied here

Rock Hill, Concord, Gastonia, Huntersville, Matthews, Mooresville. One study for diabetic nerve pain runs at Monroe, about half an hour south east of uptown. A second runs inside Charlotte for CRPS, which is a limb that turns hot and swollen after an injury. However, a plain search for nerve pain studies in Charlotte returns nothing at all, which is simply wrong. Meanwhile, we found both only by reading study records one row at a time.

So why does a search of this metro come back empty?

  • Search filters lie by omission. A condition and city search here returns zero. However, two studies are in fact open in this metro.
  • Sites are listed under the next town. Monroe is inside the metro and reads as its own city. So a Charlotte filter never sees it.
  • Facility names repeat across states. A clinic with the same name sits in Kentucky. Meanwhile, that has caught this project before, so we checked the ZIP.
  • Most nerve pain drugs were borrowed. Gabapentin came from epilepsy and duloxetine from depression. So a drug built for pain nerves is genuinely new.
  • Shingles pain has nothing anywhere. It was checked on its own across both states. In fact, there is not a single study for it here.

Research is a care option, not a last resort

There is a saying in medicine that research is a care option rather than a last resort. Generally, that is the honest way to think about a study. You are not giving up your own doctor. Instead, you are adding a second set of eyes. Notably, the study at Monroe is a tablet with no procedure in it at all, so the demanding part is a daily diary rather than anything invasive.

What being on the list actually gets you

This is a directory, not a clinic. So being on the list is simple and it costs nothing.

What you actually get

  • A call from us the day a new study opens near you
  • The clinic name and number, so you call them yourself
  • A check against every other study on our list, not just this one
  • No cost, and no insurance needed
  • Roughly $100 a visit for your time, once you are in a study
  • You are never enrolled by checking

So add it up. One study half an hour away for diabetic nerve pain, and one inside the city for a different condition. Meanwhile, your HbA1c and your first week of diary scores decide most of it. So the useful thing to do today is get your latest HbA1c and start scoring your pain each day.

What Is Actually Changing in Nerve Pain

For the first time, drugs are being built for pain nerves specifically rather than borrowed from other fields.

Nerve Pain Feels Different, and That Is the Clue

Burning, stabbing, electric shocks, pins and needles, or a numb patch that still hurts. So it does not feel like an ache or a strain, and people struggle to describe it. Meanwhile, that description is what points a doctor towards nerves rather than muscle or joint. Notably, ordinary painkillers do very little for it, which is another clue.

Diabetes Is the Commonest Cause

About half of people with long standing diabetes develop some nerve damage. So the burning feet that keep people awake are the classic picture. Meanwhile, both open studies nearest to here are aimed at exactly that group. In fact, controlling blood sugar is treatment as well as prevention.

Your HbA1c Is the Ticket In

Both nearby studies need an HbA1c of nine or under. So a number above that closes the door until it comes down. That is worth saying plainly, because getting it under nine helps the nerves anyway. Also, ask which lab result they will accept and how recent it has to be.

The Pain Window Cuts Both Ways

Studies want a weekly average between four and nine out of ten. People assume worse pain helps them qualify, and above nine actually excludes you. So does pain that jumps around a lot from day to day. Meanwhile, a steady moderate to severe score is what these studies are built around.

The Diary Is a Gate, Not Paperwork

Both nearby studies start with a seven day period of scoring your pain each day. Missing more than three of those days is a written reason to be excluded. So set an alarm, because people are turned away for this rather than for anything medical. Notably, it is the most avoidable failure in the whole process.

The Old Drugs Were Borrowed

Gabapentin and pregabalin came from epilepsy, and duloxetine came from depression. They help some people, and they leave others foggy, dizzy or unsteady. So a drug designed for pain nerves specifically is a genuinely new direction. However, whether it beats the old ones is exactly what is being measured.

Ask Whether There Is a Real Comparison Arm

One study near here compares the new tablet only against a dummy. The other, further away, adds a real approved drug as a third group. So your odds of receiving something active differ between two studies of the same drug. Meanwhile, that is a fair question to ask on the first call.

Shingles Pain and Facial Nerve Pain Have Nothing Open

Both were checked on their own rather than assumed. So there is currently no study for either anywhere in North Carolina or South Carolina. That is a statewide gap rather than a local one. Meanwhile, we will say so rather than point you at something that does not fit.

The Stimulator Is a Product, Not a Study

People are often told there is a trial for the spinal stimulator, and here there is not. We checked every stimulation study in both states, and none of them is for nerve pain. So the device is commercially available rather than experimental in this region. In fact, that means your own pain clinic is the right route, not us.

Where Things Actually Stand Locally

One study for diabetic nerve pain is open about half an hour from Charlotte, at Monroe. A second study inside Charlotte is for a different condition entirely, which is CRPS. The Midlands has nothing open, and the nearest sites are at Spartanburg and Charleston. However, a search on nerve pain in Charlotte returns nothing at all, which is simply wrong.

Nerve Pain Help Near You

Ask for your latest HbA1c, because nine or under is the gate on both nearby studies. Also, start scoring your pain daily now, since the first week decides whether you get in. Finally, ask what happens to your current nerve pain medicine before you change anything. Meanwhile, join the list and we will call you when something opens nearer to you.

Research Sites Near Charlotte

Monroe Biomedical Research sits about twenty five miles south east, and there are pain and neurology services throughout the metro. But sites add new studies all the time.

Atrium Health

Multiple Charlotte locations / 161+ active studies

Crohn’s, Heart Failure, COPD, Dementia, Type 2 Diabetes, Hypertension

Charlotte’s biggest health system. It is tied to Wake Forest University School of Medicine. Also, it runs far more trials than anyone else nearby.

Visit Website →

American Health Research Network

Ballantyne, NC 28277 / 25 to 30+ active studies

Asthma, COPD, Chronic Cough, Type 2 Diabetes

Led by Dr. Selwyn Spangenthal. It is the biggest private lung research group in Charlotte. Specifically, it has 4 offices: Charlotte, Rock Hill, Lake Norman, and Charleston.

Visit Website →

Monroe Biomedical Research

Monroe, NC / 17+ active studies

Asthma, COPD, Hypertension, Obesity, Ulcerative Colitis

Notably, one of the 5 busiest research sites in the country. Its 6,300 sq ft space can host overnight stays. It is also an SCRS Global Impact Partner.

Visit Website →

Clinical Research of Gastonia

Gastonia, NC / 11+ active studies

Asthma, COPD, Chronic Cough, Idiopathic Hypersomnia

Led by Dr. Anup Banerjee. Its 3,500 sq ft space sits next to CaroMont Regional Medical Center. Also, it has been running for over 10 years.

Visit Website →

OnSite Clinical Solutions

Ballantyne, NC 28277 / 10+ active studies

Ulcerative Colitis, Crohn’s, COPD, Heart Failure, Atopic Dermatitis

It works with Charlotte doctors in heart, gut, skin, nerve, and joint care. Besides, it runs studies from Phase I through Phase IV.

Visit Website →

Flourish Research

Matthews, NC 28105 / 4+ active studies

Alzheimer’s Disease, Early Alzheimer’s, Alzheimer’s-Related Psychosis

Led by Dr. M. Reza Bolouri. He has 20+ years in Alzheimer’s research. The site is an Alzheimer’s Center of Excellence. In fact, its network has finished 5,500+ trials.

Visit Website →

New Hope Clinical Research

SouthPark, NC 28211 / 4+ active studies

Major Depression, Schizophrenia, Bipolar Disorder

Led by Dr. Kurian Abraham. It runs Phase I through IV studies and has 30 beds for overnight stays. Its last FDA audit came back clean. Also, it has finished 200+ brain studies.

Visit Website →

Queen City Clinical Research

SouthPark, NC 28211 / 2+ active studies

Chronic Pain, Chronic Migraine, Osteoarthritis

Led by Dr. Leonardo Kapural, a former Cleveland Clinic professor. Notably, he has written 200+ journal articles. On top of that, many call this the biggest pain research site in the country.

Visit Website →

Novant Health

Multiple Charlotte locations / Several active studies

Cardiovascular Disease, Obesity, Hypertension

One of the biggest health systems in the Carolinas. Its Heart and Vascular Institute runs heart studies and sees a lot of patients.

Visit Website →

DLVSC

4 Charlotte-area offices / 1+ active studies

Eczema, Psoriasis, Rosacea

Led by Dr. Gilly Munavalli. This award-winning skin practice owns 50+ FDA-approved lasers and devices. Also, it has its own research team.

Visit Website →

DelRicht Research

South Charlotte, NC 28210 / 1+ active studies

Bipolar Disorder, Bipolar Depression

Part of a national network of mental health research sites. Currently, it runs the azetukalner bipolar depression trial in Charlotte. Previously, it ran other mental health studies.

Visit Website →

TMS of the Carolinas

South Charlotte, NC 28210 / 1+ active studies

Major Depression, Treatment-Resistant Depression

A specialty site for brain stimulation care. It runs the fast TMS study that packs 6 weeks into 2.

Visit Website →

What to Expect in a Nerve Pain Study

New to studies? Here is how one works, step by step.

01

Prescreening

First comes a short phone call or online form. Also, it takes about 10 to 15 minutes. The staff check whether you might fit. Then they tell you what is open.

02

Screening Visit

Next the clinic runs the tests that decide it, which usually means blood work. Also, they go through the consent form line by line, and you can bring somebody with you.

03

Treatment Period

Then the study begins. So you take the study drug or the placebo on the agreed schedule. Meanwhile, your own doctor keeps managing everything else.

04

Follow-Up

Finally, there is a check in period at the end. Also, your own doctor gets the results, and you can stop at any point without affecting your care.

Nerve Pain Trial FAQs

Real answers about nerve pain studies near Charlotte NC.

Is there a study for this near Charlotte?

Yes, one for diabetic nerve pain, about twenty five miles away at Monroe. It is a tablet that blocks a channel found almost only on pain sensing nerves. A second study inside Charlotte is for CRPS, which is a different condition altogether. Notably, a plain search of this metro returns neither of them, which is why we read the records directly.

How do I know if my pain is nerve pain?

By how it feels rather than where it is. Burning, stabbing, electric shocks, pins and needles, or a numb patch that still hurts. So it does not feel like an ache or a strain, and people struggle to describe it. Meanwhile, ordinary painkillers doing very little is another clue.

Why does my HbA1c matter so much?

Because both nearby studies need it to be nine or under, and that is a hard line. So a number above nine closes the door until it comes down. That is worth saying plainly, since getting it under nine helps your nerves anyway. Also, ask which lab result they will accept and how recent it has to be.

Can my pain be too bad to qualify?

Yes, and this surprises almost everybody. Studies want a weekly average between four and nine out of ten, so above nine excludes you. So does pain that jumps around a lot from one day to the next. Meanwhile, a steady moderate to severe score is exactly what these studies are built around.

What is this daily diary about?

It is a gate rather than paperwork, and people are turned away for it. Both nearby studies begin with seven days of scoring your pain each day. So missing more than three of those days is a written reason to be excluded. Notably, it is the most avoidable failure in the whole process, and an alarm fixes it.

What is CRPS, and why is it listed here?

After an injury, one limb sometimes becomes intensely painful, red, hot and swollen, far beyond the injury itself. So it is managed in the same clinics as nerve pain, and people searching for nerve pain will find it. However, it is not the same condition, and the study specifically excludes people with a known nerve injury. Also, you have to be within six months of it starting, which rules out most people who reach a listing.

Is there a trial for the spinal stimulator?

Not here, and people are often told otherwise. We checked every stimulation study in both Carolinas, and none of them is for nerve pain. So the device is commercially available rather than experimental in this region. In fact, that means your own pain clinic is the right route for it, not us.

Does it cost anything to check?

No. There is no cost, and no insurance is needed. Tether is a nonprofit list, so we do not run studies and we are not paid to send you anywhere. Also, checking never enrolls anyone in anything. You would always call the clinic yourself.

Where can I get help near Charlotte?

Atrium Health and Novant Health both run pain and neurology services across the metro. Also, ask for your latest HbA1c, because it is the gate on the nearby study. Generally, your own doctor manages the diabetes side, and a pain clinic handles the rest. Meanwhile, ask before changing any nerve pain medicine you already take.

Ready to Explore a Study?

Check your eligibility, or just reach out to our Charlotte team. No pressure. Also, no sales pitch.

← Back to All Clinical Trials

Sources

Study details and per-site recruiting status verified against ClinicalTrials.gov on August 17, 2026. A plain search for neuropathic pain in Charlotte returns nothing, while two studies are in fact open in the metro. That is the clearest false zero this project has found, and it is why condition and city searches are never trusted on their own. The Monroe NC site was re-checked deliberately, because a facility of that name has previously resolved to Louisville KY on a different study. On this record the state reads North Carolina and the ZIP is 28112, which is Monroe in Union County. Shingles pain and facial nerve pain were swept separately against both states and returned zero recruiting studies statewide. Spinal cord stimulation was also swept separately, and no stimulation trial for nerve pain is open in either state. Study availability and criteria change; the research clinic confirms everything before you enroll.

See which nerve pain studies near Charlotte fit me →